Amorphous solid dispersions of amphiphilic polymer excipients and indomethacin prepared by hot melt extrusion

被引:0
作者
Kessler, Larissa [1 ,2 ]
Mishra, Rashmi [3 ]
Hietala, Sami [4 ]
Lammens, Manon [3 ,9 ]
Peltonen, Leena [3 ]
Rades, Thomas [5 ]
van Veen, Bert [6 ]
Juppo, Anne [3 ]
Laaksonen, Timo [7 ,8 ]
Strachan, Clare [3 ]
Luxenhofer, Robert [1 ,2 ]
机构
[1] Univ Helsinki, Dept Chem, Soft Matter Chem, Helsinki 00014, Finland
[2] Univ Helsinki, Helsinki Inst Sustainabil Sci, Fac Sci, Helsinki 00014, Finland
[3] Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, Helsinki 00790, Finland
[4] Univ Helsinki, Dept Chem, POB 55, FIN-00014 Helsinki, Finland
[5] Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark
[6] Orion Corp, Pharmaceut Sci, Espoo 02200, Finland
[7] Univ Helsinki, Fac Pharm, Div Pharmaceut Biosci, Helsinki 00790, Finland
[8] Tampere Univ, Fac Engn & Nat Sci, Tampere 33101, Finland
[9] Univ Ghent, Lab Pharmaceut Technol, B-9000 Ghent, Belgium
基金
芬兰科学院;
关键词
Amphiphilic block copolymer; Poly(2-oxazoline); Poly(2-oxazine); Drug formulation; Poly(vinyl pyrrolidone); Poly(vinyl pyrrolidone-co-vinyl acetate); GRADIENT COPOLYMERS; POLY(VINYLPYRROLIDONE); STABILIZATION; TEMPERATURE; FORMULATION; SOLUBILITY;
D O I
10.1016/j.ejps.2024.106960
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Improving the solubility of poorly water-soluble drugs is essential for enhancing bioavailability, formulation flexibility and reducing patient-to-patient variability. The preparation of amorphous solid dispersions (ASDs) is an attractive strategy to formulate such drugs, leading to higher apparent water solubility and therefore higher bioavailability. For such ASDs, water-soluble polymer excipients, such as poly(vinyl pyrrolidone) (PVP) or poly (vinyl pyrrolidone-co-vinyl acetate) (P(VP-co-VA)), are employed to solubilize and stabilize the drug against crystallization. We posit that polymers bearing tertiary amides are particularly well suited to stabilizing drugs containing H-bond donors, as they offer strong H-bonding potential between the polymer and drug. The aim of this study was to compare new and established polymers with tertiary amides as excipients for ASDs. Experimental amphiphilic ABA triblock copolymers comprising poly(2-methyl-2-oxazoline) (pMeOx), poly(2-butyl-2oxazoline) (pBuOx) and poly(2-butyl-2-oxazine) (pBuOzi) blocks, were compared with the established excipients, PVP and P(VP-co-VA). ASDs with indomethacin as the model drug were prepared at high drug loadings via hot melt extrusion. The extrudates were studied with DSC and PXRD, revealing the ASDs to be fully amorphous up to 75wt% indomethacin, independent of the polymer used. 13C CPMAS NMR provided insights into intermolecular associations as a function of drug loading, and suggested the presence of drug dimers at 75wt% drug loading in pMeOx-pBuOzi-pMeOx and pMeOx-pBuOx-pMeOx, which could affect physical stability. Independent of the polymers, the solid-state form of the drug in the ASD was found to affect the dissolution profile of the samples, insofar as the samples containing crystalline indomethacin showed slower dissolution than the fully amorphous ones. This study shows that the polymers comprising poly(2-oxazoline) and poly(2-oxazine) are effective polymers for ASD preparation, similar to PVP and P(VP-co-VA) which merits further investigations into these novel polymers for formulating ASDs.
引用
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页数:11
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