The future of food allergy diagnosis

被引:1
|
作者
Wong, Dominic S. H. [1 ]
Santos, Alexandra F. [2 ,3 ,4 ]
机构
[1] Kings Coll London, GKT Sch Med Educ, London, England
[2] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth Paediatr Allergy, London, England
[3] Kings Coll London, Sch Immunol & Microbial Sci, Peter Gorer Dept Immunobiol, London, England
[4] Guys & St Thomas Hosp, Evelina London Childrens Hosp, Childrens Allergy Serv, London, England
来源
FRONTIERS IN ALLERGY | 2024年 / 5卷
关键词
food allergy; diagnosis; molecular allergology; basophil activation test; mast cell activation test; bead-based epitope assay; T cell assays; microbiome analysis; BASOPHIL ACTIVATION TEST; PEANUT ALLERGY; THRESHOLD-SENSITIVITY; HAZELNUT ALLERGY; COWS MILK; T-CELLS; IGE; SENSITIZATION; ANTIBODIES; COMPONENTS;
D O I
10.3389/falgy.2024.1456585
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Food allergy represents an increasing global health issue, significantly impacting society on a personal and on a systems-wide level. The gold standard for diagnosing food allergy, the oral food challenge, is time-consuming, expensive, and carries risks of allergic reactions, with unpredictable severity. There is, therefore, an urgent need for more accurate, scalable, predictive diagnostic techniques. In this review, we discuss possible future directions in the world of food allergy diagnosis. We start by describing the current clinical approach to food allergy diagnosis, highlighting novel diagnostic methods recommended for use in clinical practice, such as the basophil activation test and molecular allergology, and go on to discuss tests that require more research before they can be applied to routine clinical use, including the mast cell activation test and bead-based epitope assay. Finally, we consider exploratory approaches, such as IgE glycosylation, IgG4, T and B cell assays, microbiome analysis, and plasma cytokines. Artificial intelligence is assessed for potential integrated interpretation of panels of diagnostic tests. Overall, a framework is proposed suggesting how combining established and emerging technologies can effectively enhance the accuracy of food allergy diagnosis in the future.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Biomarkers of diagnosis and resolution of food allergy
    Foong, Ru-Xin
    Santos, Alexandra F.
    PEDIATRIC ALLERGY AND IMMUNOLOGY, 2021, 32 (02) : 223 - 233
  • [2] Diagnosis of Food Allergy
    Gupta, Malika
    Cox, Amanda
    Nowak-Wegrzyn, Anna
    Wang, Julie
    IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2018, 38 (01) : 39 - +
  • [3] Basophil activation test in the food allergy clinic: its current use and future applications
    Bergmann, Marcel M.
    Santos, Alexandra F.
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2024, 20 (11) : 1297 - 1304
  • [4] Improving Diagnostic Accuracy in Food Allergy
    Foong, Ru-Xin
    Dantzer, Jennifer A.
    Wood, Robert A.
    Santos, Alexandra F.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2021, 9 (01): : 71 - 80
  • [5] Optimizing the Diagnosis of Food Allergy
    Kattan, Jacob D.
    Sicherer, Scott H.
    IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2015, 35 (01) : 61 - +
  • [6] Update on food allergy
    Peters, Rachel L.
    Krawiec, Marta
    Koplin, Jennifer J.
    Santos, Alexandra F.
    PEDIATRIC ALLERGY AND IMMUNOLOGY, 2021, 32 (04) : 647 - 657
  • [7] Novel diagnostics in food allergy
    Boyd, Holly
    Santos, Alexandra F.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2025, 155 (02) : 275 - 285
  • [8] Food allergy severity predictions based on cellular in vitro tests
    Buyuktiryaki, Betul
    Santos, Alexandra F.
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2020, 20 (07) : 679 - 691
  • [9] Food allergy: management, diagnosis and treatment strategies
    Gomez, Enrique
    Mayorga, Cristobalina
    Gomez, Francisca
    Belen Blazquez, Ana
    Diaz-Perales, Araceli
    Blanca, Miguel
    Jose Torres, Maria
    IMMUNOTHERAPY, 2013, 5 (07) : 755 - 768
  • [10] Allergen Component Testing in the Diagnosis of Food Allergy
    Schussler, Edith
    Kattan, Jacob
    CURRENT ALLERGY AND ASTHMA REPORTS, 2015, 15 (09)