The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives

被引：0
|
作者：
Hua, Shuanghui [1 ]
Moon, Jimin [1 ]
Lee, Taeho [1 ]
机构：
[1] Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, 80 Daehak Ro, Daegu 702701, South Korea
来源：
MOLECULES | 2025年 / 30卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
thiazole; solid-phase synthesis; chemical library; DESIGN;
D O I：
10.3390/molecules30020430
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-d]pyrimidin-7(6H)-one structure was synthesized through efficient Thorpe-Ziegler and cyclization reactions. The thiazolo[4,5-d]pyrimidin-7(6H)-one derivative library with a diversity of three had a total of four synthesis steps and 57 compounds. In addition, the yield per synthesis step was 65-97%, which was very high. The developed synthesis method and compounds will be used to find compounds with biological activity through the thiazole derivative structure-activity relationship.
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页数：10
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