In the Brain of Phosphodiesterases: Potential Therapeutic Targets for Schizophrenia

被引：0

作者：

Barbagallo, Federica ^{[1
]}

Assenza, Maria Rita ^{[1
]}

Messina, Antonino ^{[2
]}

机构：

[1] Kore Univ Enna, Dept Med & Surg, Enna, Italy

[2] Enna Hosp, Dept Mental Hlth Enna, Psychiat Unity, Enna, Italy

来源：

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | 2025年 / 23卷 / 01期

关键词：

Neuroinflammatory diseases; Phosphodiesterase inhibitors; Adenosine cyclic monophosphate; Guanosine cyclic monophosphate; Neuronal plasticity; Schizophrenia; MESSENGER-RNA; SUBCELLULAR-LOCALIZATION; VENTRAL HIPPOCAMPUS; PDE10A INHIBITOR; SPLICE VARIANTS; EMERGING ROLE; CYCLIC-AMP; EXPRESSION; GENE; IDENTIFICATION;

D O I：

10.9758/cpn.24.1229

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracellular cyclic nucleotides (cyclic adenosine monophosphate and cyclic guanosine monophosphate) and downstream cellular signal transduction are regulated by phosphodiesterases (PDEs). The neuroplasticity, neurotransmitter pathways, and neuroinflammation-controlling functions of PDEs were demonstrated in numerous in vitro and animal model studies. We comprehensively reviewed the literature regarding the expression of PDEs in various brain regions. Subsequently, articles regarding schizophrenia and PDEs were examined. The pathophysiological mechanisms of schizophrenia and PDEs in preclinical and clinical investigations are briefly reviewed. Particularly for those who do not respond to conventional antipsychotics, specific PDE inhibitors may offer innovative therapeutic alternatives. Although the connection between schizophrenia and PDEs is intriguing, additional research is required. Comprehending the brain's PDE isoforms, their therapeutic potential, and any adverse effects of inhibiting them is essential for progress in this field.

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页码：15 / 31

页数：17

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