Antimicrobial Peptides and Their Mimetics: Promising Candidates of Next-Generation Therapeutic Agents Combating Multidrug-Resistant Bacteria

被引：4

作者：

Zhang, Tianyi ^{[1
]}

Jin, Qiao ^{[1
]}

Ji, Jian ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 2, State Key Lab Transvasc Implantat Devices, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Peoples R China

来源：

ADVANCED BIOLOGY | 2025年 / 9卷 / 04期

基金：

中国国家自然科学基金;

关键词：

antimicrobial peptides; artificial intelligence; chemical mimetics; computer-guided design; multi-drug resistance; AMINO-ACID SUBSTITUTION; HOST-DEFENSE PEPTIDES; PRECURSOR LIPID II; ANTIBACTERIAL PEPTIDES; MEMBRANE INTERACTIONS; SECONDARY STRUCTURE; ANTIBIOTIC-RESISTANCE; HUMAN BETA-DEFENSIN-3; HEMOLYTIC ACTIVITIES; RATIONAL DESIGN;

D O I：

10.1002/adbi.202400461

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The increasing morbidity and mortality caused by multidrug-resistant bacteria alerts human beings to the fact that conventional antibiotics are no longer reliable and effective alternatives are imperatively needed. Owing to wide range of sources, diverse structures, and unique mode of action, antimicrobial peptides have been highly anticipated and extensively studied in recent years. Besides, the integration of artificial intelligence helps researchers gain access to the vast unexplored chemical space, which opens more opportunities for the optimization and design of novel structures. Moreover, Due to advances in chemistry and synthetic biology, researchers have also begun to focus on the potential of chemical mimetics of antimicrobial peptides. In this review, a comprehensive discussion about natural and synthesized antimicrobial peptides as well as their chemical mimetics is made, so as to provide a comprehensive summary of this field and inspire follow-up research.

引用

页数：20

共 272 条

[1]

Adedeji W A, 2016, Ann Ib Postgrad Med, V14, P56

[2] Antimicrobial and Antibiofilm Activities of Helical Antimicrobial Peptide Sequences Incorporating Metal-Binding Motifs [J].

Agbale, Caleb M. ;

Sarfo, Justice K. ;

Galyuon, Isaac K. ;

Juliano, Samuel A. ;

Silva, Gislaine G. O. ;

Buccini, Danieli F. ;

Cardoso, Marlon H. ;

Torres, Marcelo D. T. ;

Angeles-Boza, Alfredo M. ;

de la Fuente-Nunez, Cesar ;

Franco, Octavio L. .

BIOCHEMISTRY, 2019, 58 (36) :3802-3812

[3] Emerging Computational Approaches for Antimicrobial Peptide Discovery [J].

Aguero-Chapin, Guillermin ;

Galpert-Canizares, Deborah ;

Dominguez-Perez, Dany ;

Marrero-Ponce, Yovani ;

Perez-Machado, Gisselle ;

Teijeira, Marta ;

Antunes, Agostinho .

ANTIBIOTICS-BASEL, 2022, 11 (07)

[4] Antimicrobial Peptide Engineering: Rational Design, Synthesis, and Synergistic Effect [J].

Ajingi, Ya'u Sabo ;

Jongruja, Nujarin .

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2020, 46 (04) :463-479

[5] Measuring Thousands of Single-Vesicle Leakage Events Reveals the Mode of Action of Antimicrobial Peptides [J].

Al Nahas, Kareem ;

Fletcher, Marcus ;

Hammond, Katharine ;

Nehls, Christian ;

Cama, Jehangir ;

Ryadnov, Maxim G. ;

Keyser, Ulrich F. .

ANALYTICAL CHEMISTRY, 2022, 27 (9530-9539) :9530-9539

[6] Amino Terminal Copper and Nickel Binding Motif Derivatives of Ovispirin-3 Display Increased Antimicrobial Activity via Lipid Oxidation [J].

Alexander, Jessica L. ;

Yu, Zhen ;

Cowan, J. A. .

JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (24) :10047-10055

[7] Global antimicrobial-resistance drivers: an ecological country-level study at the human-animal interface [J].

Allel, Kasim ;

Day, Lucy ;

Hamilton, Alisa ;

Lin, Leesa ;

Furuya-Kanamori, Luis ;

Moore, Catrin E. ;

Van Boeckel, Thomas ;

Laxminarayan, Ramanan ;

Yakob, Laith .

LANCET PLANETARY HEALTH, 2023, 7 (04) :E291-E303

[8] Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides [J].

Almaaytah, Ammar ;

Qaoud, Mohammed T. ;

Abualhaijaa, Ahmad ;

Al-Balas, Qosay ;

Alzoubi, Karem H. .

INFECTION AND DRUG RESISTANCE, 2018, 11 :835-847

[9] In-Vitro and In-Vivo Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens [J].

Almutairi, Megren Bin Faisal ;

Alrouji, Mohammed ;

Almuhanna, Yasir ;

Asad, Mohammed ;

Joseph, Babu .

ANTIBIOTICS-BASEL, 2022, 11 (11)

[10]

Anderson RA, 2000, J ANDROL, V21, P862

← 1 2 3 4 5 6 7 8 9 10 →