EFFECTS OF APPROVED PHARMACOLOGICAL INTERVENTIONS FOR INSOMNIA ON MOOD DISORDERS: A SYSTEMATIC REVIEW

被引:2
|
作者
Palagini, Laura [1 ,2 ]
Miniati, Mario [1 ,2 ]
Marazziti, Donatella [1 ,2 ]
Riemann, Dieter [3 ]
Geoffroy, Pierre A. [4 ,5 ,6 ,7 ]
Gemignani, Angelo [8 ,9 ]
机构
[1] Univ Pisa, Dept Neurosci, Psychiat Sect, Pisa, Italy
[2] Azienda Osped Univ Pisana AUOP, Pisa, Italy
[3] Univ Freiburg, Ctr Mental Disorders, Dept Clin Psychol & Psychophysiol Sleep Med, Freiburg, Germany
[4] Hop Bichat Claude Bernard, AP HP, Dept Psychiat & addictol, GHU Paris Nord,DMU Neurosci, Paris, France
[5] GHU Paris Psychiat & Neurosci, Paris, France
[6] Univ Paris, NeuroDiderot, INSERM, Paris, France
[7] CNRS, Inst Cellular & Integrat Neurosci, UPR 3212, Strasbourg, France
[8] Univ Pisa, Dept Surg Med & Mol Pathol Crit & Care Med, Pisa, Italy
[9] Azienda Osped Univ Pisana AUOP, Dept Neurosci, Pisa, Italy
来源
CLINICAL NEUROPSYCHIATRY | 2024年 / 21卷 / 04期
关键词
insomnia; mood disorders; hypnotics; benzodiazepines; z-drugs; melatonin 2 mg pr; daridorexant; suvorexant; PLACEBO-CONTROLLED TRIAL; SLOW-RELEASE MELATONIN; BIPOLAR I DISORDER; QUALITY-OF-LIFE; DOUBLE-BLIND; ESZOPICLONE TREATMENT; ADJUNCTIVE RAMELTEON; SLEEP DISTURBANCE; FLUOXETINE; SCHIZOPHRENIA;
D O I
10.36131/cnfioritieditore20240504
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Insomnia can be a contributing factor, a comorbid disorder, or a transdiagnostic element to several mental disorders, including mood disorders (MDs). A recent meta-analysis has already shown the effectiveness of cognitive behavioral treatment (CBT) for insomnia that is comorbid with MDs. This work aimed to systematically review data on pharmacological insomnia treatment in the context of MDS. In agreement with the current guidelines, pharmacological interventions for insomnia include gamma-aminobutyric acid (GABA)A receptor agonists such as short-medium acting benzodiazepines and benzodiazepine receptor agonists- Z-drugs, melatonergic receptors agonists, specifically melatonin 2 mg Prolonged Release (PR) and ramelteon, and dual orexin receptors antagonists (DORA) such as daridorexant, lemborexant, and suvorexant. Method: A systematic search was carried out on PUBMED database, according to the PRISMA Guidelines. Results: Thirty-three papers, 15 on gabaergic receptor agonists, 14 on melatonergic receptor agonists and 4 on DORA, were selected. Conclusions: Available data suggests that the treatment of insomnia symptoms with specific pharmacological options can improve both insomnia and comorbid conditions. Specifically, eszopiclone and melatonin 2 mg PR have demonstrated promising outcomes. Moreover, daridorexant and suvorexant, both belonging to the DORA class, have demonstrated efficacy in treating insomnia and mood symptoms. To summarize, current literature would suggest that targeting insomnia could potentially regulate the sleep system and, as such, improve mood symptoms.
引用
收藏
页码:385 / 402
页数:18
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