Alcohol-Metabolizing Enzymes, Liver Diseases and Cancer

被引：0
作者：
Liu, Tao [1 ,2 ,3 ]
Zhang, FeiYu [1 ,2 ,3 ]
Feng, Yue [1 ,2 ,3 ]
Han, PanShiLi [1 ,2 ,3 ]
Gao, YanHang [1 ,2 ,3 ]
机构：
[1] First Hosp Jilin Univ, Ctr Infect Dis & Pathogen Biol, Dept Hepatol, Changchun, Peoples R China
[2] China Singapore Belt & Rd Joint Lab Liver Dis Res, Changchun, Peoples R China
[3] Jilin Univ, Jilin Prov Key Lab Metab Liver Dis, Changchun, Peoples R China
来源：
SEMINARS IN LIVER DISEASE | 2025年
基金：
中国国家自然科学基金;
关键词：
ADH; ALDH; liver disease; liver cancer; ALDEHYDE DEHYDROGENASE 2; HEPATOCELLULAR-CARCINOMA; CYTOCHROME-P450; 2E1; FATTY LIVER; GENETIC POLYMORPHISMS; ETHANOL-METABOLISM; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADH ISOENZYMES; MESSENGER-RNA;
D O I：
10.1055/a-2551-3320
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Alcohol is generally believed to be metabolized in the liver by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and to a much lesser extent cytochrome P450 2E1 (CYP2E1) and other enzymes. Recent studies suggest that gut also play important roles in the promotion of alcohol metabolism. ADH, ALDH, and CYP2E1 have several polymorphisms that markedly impact alcohol metabolism. These alcohol-metabolizing enzymes not only affect alcohol-associated liver disease (ALD), but may also modulate the pathogenesis of other liver diseases and cancer in the absence of alcohol consumption. In this review, we discuss alcohol metabolism and the roles of alcohol-metabolizing enzymes in the pathogenesis of ALD, metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction and alcohol-associated liver disease, viral hepatitis, and liver cancer. We also discuss how alcohol-metabolizing enzymes may affect endogenous ethanol production, and how ethanol metabolism in the gut affects liver disease and cancer. Directions for future research on the roles of alcohol- metabolizing enzymes in liver disease and cancer are also elaborated.
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页数：15
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  • [1] Global status report on alcohol and health and treatment of substance use disorders, (2024)
  • [2] Jiang Y., Zhang T., Kusumanchi P., Han S., Yang Z., Liangpunsakul S., Alcohol metabolizing enzymes, microsomal ethanol oxidizing system, cytochrome P450 2E1, catalase, and aldehyde dehydrogenase in alcohol-associated liver disease, Biomedicines, 8, (2020)
  • [3] Guillot A., Ren T., Jourdan T., Et al., Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking, Proc Natl Acad Sci U S A, 116, 51, pp. 25974-25981, (2019)
  • [4] Mackowiak B., Fu Y., Maccioni L., Gao B., Alcohol-associated liver disease, J Clin Invest, 134, (2024)
  • [5] Boffetta P., Hashibe M., Alcohol and cancer, Lancet Oncol, 7, pp. 149-156, (2006)
  • [6] Paton A., Alcohol in the body, BMJ, 330, 7482, pp. 85-87, (2005)
  • [7] Cederbaum A.I., Alcohol metabolism, Clin Liver Dis, 16, pp. 667-685, (2012)
  • [8] Beck I.T., Paloschi G.B., Dinda P.K., Beck M., Effect of intragastric administration of alcohol on the ethanol concentrations and osmolality of pancreatic juice, bile, and portal and peripheral blood, Gastroenterology, 67, pp. 484-489, (1974)
  • [9] Fu Y., Mackowiak B., Lin Y.H., Et al., Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption, Nat Metab, 6, pp. 1380-1396, (2024)
  • [10] Maccioni L., Fu Y., Horsmans Y., Et al., Alcohol-associated bowel disease: new insights into pathogenesis, eGastroenterology, 1, (2023)
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