Multisystem inflammatory syndrome in children (MIS-C) cases by vaccination status in California

被引：1

作者：

Le Marchand, Chloe ^{[1
]}

Singson, Jason Robert C. ^{[1
,2
]}

Clark, Amy ^{[1
]}

Shah, Dhawani ^{[1
]}

Wong, Monice ^{[1
]}

Chavez, Sebastian ^{[1
]}

Naguit, Marijoyce ^{[1
]}

Nelson, Lauren ^{[1
]}

Rosen, Hilary ^{[1
]}

Jain, Seema ^{[1
]}

Openshaw, John J. ^{[1
,3
]}

机构：

[1] Calif Dept Publ Hlth, Richmond, CA 94804 USA

[2] CSTE Appl Epidemiol Fellowship, Atlanta, GA USA

[3] Stanford Univ, Div Infect Dis & Geog Med, Stanford, CA USA

来源：

VACCINE | 2025年 / 43卷

关键词：

Multisystem inflammatory syndrome in; children; COVID-19; Vaccination;

D O I：

10.1016/j.vaccine.2024.126499

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multisystem inflammatory syndrome in children (MIS-C) is a rare condition occurring after SARS-CoV-2 infection in children under 21 years of age. Children (5-17 years) with MIS-C meeting the Centers for Disease Control (CDC) case definition were reported via California's passive disease surveillance system. Incidence of MIS-C was compared in unvaccinated and Pfizer-BioNTech vaccinated children aged 12-17 and 5-11 years. In the 12-17 year-old age group, there were 66 new cases among 872,936 unvaccinated children and 7 new cases among 2,117,575 vaccinated children. In the 5-11 year-old age group, there were 51 new cases among 2,113,725 unvaccinated children and 9 new cases among 1,221,293 vaccinated children. Compared with vaccinated children, the incident rate ratio of MIS-C was higher among unvaccinated children in both the 12-17-year-old group (22.9, 95 % confidence interval [CI]: 10.5-49.8, p <0.0001) and the 5-11-year-old group (3.3, 95 % CI: 1.6-6.7, p = 0.0004). While MIS-C is rare, our results suggest that vaccination with the Pfizer-BioNTech vaccine is protective against MIS-C.

引用

页数：5

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