Neutrophil-To-Lymphocyte Ratio as a Prognostic Indicator in Thyroid Cancer

被引：0

作者：

Gao, Qiangang ^{[1
]}

Quan, Mingming ^{[2
]}

Zhang, Lilong ^{[3
]}

Ran, Yanyun ^{[4
]}

Zhong, Jijun ^{[1
]}

Wang, Bin ^{[5
]}

机构：

[1] Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Nucl Med, Taizhou, Peoples R China

[2] Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Surg Oncol, Taizhou, Peoples R China

[3] Wuhan Univ, Dept Gen Surg, Renmin Hosp, Wuhan, Peoples R China

[4] Taizhou Univ Hosp, Taizhou Cent Hosp, Precis Med Ctr, Taizhou, Peoples R China

[5] Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Radiol, 999 Donghai Ave, Taizhou 318000, Zhejiang, Peoples R China

来源：

CANCER CONTROL | 2024年 / 31卷

关键词：

neutrophil-to-lymphocyte ratio; thyroid cancer; prognosis; surgery; sorafenib; lenvatinib; UNITED-STATES; MONOCYTE RATIO; IMMUNE CELLS; CARCINOMA; RISK; INFILTRATION; INFLAMMATION; ACTIVATION; MIXTURE; VALUES;

D O I：

10.1177/10732748241309048

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: In this study, we aimed to perform a comprehensive analysis to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR) levels in patients diagnosed with thyroid cancer. Methods: We systematically searched multiple databases, including PubMed, the Cochrane Library, EMBASE, and Google Scholar, up until March 30, 2023, to identify relevant articles. The clinical outcomes evaluated in this study included overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), and cause-specific survival (CSS). Results: This analysis includes 21 articles with 5187 patients in total. The pooled results revealed that patients with high NLR levels had significantly poorer OS (HR: 2.578, 95% CI: 2.050-3.242, P < 0.001), PFS (HR: 2.143, 95% CI: 1.616-2.843, P < 0.001), DFS (HR: 1.377, 95% CI: 1.045-1.816, P = 0.023), and CSS (HR: 2.842, 95% CI: 1.334-6.053, P = 0.007). The subgroup analyses were performed based on different study regions, treatment modalities, cancer types, and NLR cut-off values, and the above conclusion remained consistent in the majority of subgroup analyses. The stability and reliability of the aforementioned results were supported by the sensitivity analysis and publication bias test. Conclusion: The baseline NLR levels were useful predictors of outcomes in patients with thyroid cancer.

引用

页数：11

共 60 条

[1]

Puliafito I., Esposito F., Prestifilippo A., Et al., Target therapy in thyroid cancer: current challenge in clinical use of tyrosine kinase inhibitors and management of side effects, Front Endocrinol, 13, (2022)

[2]

Davies L., Welch H.G., Increasing incidence of thyroid cancer in the United States, 1973-2002, JAMA, 295, 18, pp. 2164-2167, (2006)

[3]

Davies L., Welch H.G., Current thyroid cancer trends in the United States, JAMA Otolaryngol Head Neck Surg, 140, 4, pp. 317-322, (2014)

[4]

Kent W.D., Hall S.F., Isotalo P.A., Houlden R.L., George R.L., Groome P.A., Increased incidence of differentiated thyroid carcinoma and detection of subclinical disease, CMAJ (Can Med Assoc J), 177, 11, pp. 1357-1361, (2007)

[5]

Enewold L., Zhu K., Ron E., Et al., Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005, Cancer Epidemiol Biomarkers Prev, 18, 3, pp. 784-791, (2009)

[6]

Lim H., Devesa S.S., Sosa J.A., Check D., Kitahara C.M., Trends in thyroid cancer incidence and mortality in the United States, 1974-2013, JAMA, 317, 13, pp. 1338-1348, (2017)

[7]

Zhang L., Feng J., Kuang T., Et al., Blood biomarkers predict outcomes in patients with hepatocellular carcinoma treated with immune checkpoint Inhibitors: a pooled analysis of 44 retrospective sudies, Int Immunopharm, 118, (2023)

[8]

Zhang Q., Zhang L., Jin Q., Et al., The prognostic value of the GNRI in patients with stomach cancer undergoing surgery, J Personalized Med, 13, 1, (2023)

[9]

Moon H., Roh J.L., Lee S.W., Et al., Prognostic value of nutritional and hematologic markers in head and neck squamous cell carcinoma treated by chemoradiotherapy, Radiother Oncol, 118, 2, pp. 330-334, (2016)

[10]

Azab B., Mohammad F., Shah N., Et al., The value of the pretreatment neutrophil lymphocyte ratio vs. platelet lymphocyte ratio in predicting the long-term survival in colorectal cancer, Cancer Biomarkers, 14, 5, pp. 303-312, (2014)

← 1 2 3 4 5 6 →