Cytotoxic Potential of Simarouba glauca Leaf Extracts on PA1 Human Ovarian Cancer Cell Lines

被引：1

作者：

Shettar, Priyadarshini S. ^{[1
]}

Kumbar, Vijay M. ^{[2
]}

Hiremath, Murigendra B. ^{[1
]}

机构：

[1] Karnatak Univ, Dept Biotechnol & Microbiol, Dharwad 580003, Karnataka, India

[2] KLE Univ, KLE Acad Higher Educ & Res, Dr Prabhakar Kore Basic Sci Res Ctr, Belgaum, Karnataka, India

来源：

JOURNAL OF HERBS SPICES AND MEDICINAL PLANTS | 2024年

关键词：

Cytotoxicity; anti-oxidant activity; ANTIOXIDANT; CONSTITUENTS; QUASSINOIDS; PLANTS;

D O I：

10.1080/10496475.2024.2428620

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The phytochemical composition, anti-oxidant and cytotoxic potential of Simarouba glauca leaf extracts were examined. The anti-oxidant activity was determined by DPPH, PM and FRAP assays. The determination of cell viability was performed by MTT assay. The acetone and methanol extracts showed higher anti-oxidant capacities than other extracts. The methanol and acetone extracts inhibited PA1 ovarian cancer cell growth in a dose-dependent manner with IC50 values 106.67 +/- 1.53 mu g/ml-1 and 124.43 +/- 3.04 mu g/ml-1, respectively, compared to the standard drug Doxorubicin (IC50 = 2.91 +/- 0.03 mu g/ml-1). The selectivity of the plant proved to have a promising anti-cancer potential by inhibiting PA1 ovarian cancer cell lines.

引用

页码：66 / 78

页数：13

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