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Extracellular DNA-protein interactions
被引:2
|作者:
Goodman, Steven D.
[1
]
机构:
[1] Ohio State Univ, Abigail Wexner Res Inst, Nationwide Childrens Hosp, Ctr Microbial Pathogenesis,Coll Med, 700 Childrens Dr,WA5021, Columbus, OH 43205 USA
基金:
美国国家卫生研究院;
关键词:
INTEGRATION HOST FACTOR;
HISTONE-LIKE PROTEIN;
B-DNA;
BINDING PROTEIN;
HU;
BIOFILMS;
DODECAMER;
CHROMATIN;
REVEALS;
FAMILY;
D O I:
10.1016/j.sbi.2024.102943
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Intracellular DNA primarily serves as the cellular genetic material both in eukaryotes and prokaryotes. This function is often regulated by alterations in the DNA structure to accommodate larly, both eukaryotic and prokaryotic cells take advantage of DNA plenty in addition to a permissive environment and create novel structures to fulfill multiple new roles. As often occurs intracellularly, extracellular DNA requires proteins to facilitate and stabilize these important structures. Here I review, both host and eubacterial nucleoprotein structures, their composition, their functions, and how these distinct structures can interact. Even at this early stage of study, it is clear that extracellular chromatin plays important biological roles in the survival of both prokaryotic and eukaryotic organisms.
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