Relationship Between Postoperative Oxidative Stress Levels and Corneal Endothelial Cell Loss After Phacoemulsification in Diabetic Patients with Cataract

被引：0

作者：

Gao, Yuan ^{[1
]}

Yang, Ning ^{[1
]}

Wei, Lijuan ^{[1
]}

Yan, Yijie ^{[1
]}

Li, Lei ^{[1
]}

机构：

[1] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Ophthalmol, 19 Xiuhua Rd, Haikou 570311, Hainan, Peoples R China

来源：

CLINICAL OPHTHALMOLOGY | 2024年 / 18卷

关键词：

diabetic cataract; phacoemulsification; oxidative stress; corneal endothelial cell loss; correlation; SUPEROXIDE-DISMUTASE; THICKNESS;

D O I：

10.2147/OPTH.S497133

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Objective: To investigate the relationship between postoperative oxidative stress and corneal endothelial cell loss in diabetic patients with cataract. Methods: One hundred and twenty patients who underwent phacoemulsification were selected, including 80 diabetic patients with cataract and 40 patients with ordinary cataracts. Corneal endothelial cell loss was recorded, and the endothelial cell density (ECD), the proportion of hexagonal cells, and the corneal thickness within the central corneal area were compared. According to the severity of endothelial cell loss, the diabetic patients with cataract were divided into a general loss group (n = 37) and a serious loss group (n = 43), and the postoperative serum superoxide dismutase (SOD), malonaldehyde (MDA), and glutathione peroxidase (GSH-Px) were measured. The relationship between oxidative stress factors and corneal endothelial cell loss in diabetic patients with cataract was analyzed, and the predictive value of MDA, SOD, and GSH-Px was investigated by using receiver operating characteristic (ROC) curve. Results: Diabetic patients with cataract had higher serum MDA and lower SOD and GSH-px, and higher fasting blood glucose concentration, glycosylated hemoglobin level, and low-density lipoprotein cholesterol (P < 0.05). The mean change in ECD in diabetic patients with cataract was 10.95%, which was greater than the 6.11% in non-diabetic patients with cataract (P < 0.05), and the proportion of hexagonal cells decreased and corneal thickness increased. MDA levels was negatively correlated with corneal endothelial cell loss in diabetic patients with cataract (r(s) = 0.509), and SOD and GSH-px were negatively correlated (r(s) = -0.361, r(s) = -0.482). The area under the ROC curve of MDA, SOD, and GSH-px in corneal endothelial cell loss was 0.719, 0.773, and 0.752, respectively. Conclusion: The degree of postoperative corneal endothelial cell loss in diabetic patients with cataract was greater and positively correlated with MDA, and negatively correlated with SOD and GSH-px.

引用

页码：3957 / 3965

页数：9

共 24 条

[1]

Mohammadi SF, Hashemi H, Mazouri A, Et al., Outcomes of cataract surgery at a referral center, J Ophthalmic Vis Res, 10, 3, pp. 250-256, (2015)

[2]

Memon AF, Mahar PS, Memon MS, Mumtaz SN, Shaikh SA, Fahim MF., Age-related cataract and its types in patients with and without type 2 diabetes mellitus: a Hospital-based comparative study, J Pak Med Assoc, 66, 10, pp. 1272-1276, (2016)

[3]

Mrugacz M, Pony-Uram M, Bryl A, Zorena K., Current approach to the pathogenesis of diabetic cataracts, Int J Mol Sci, 24, 7, (2023)

[4]

Kaji Y, Usui T, Oshika T, Et al., Advanced glycation end products in diabetic corneas, Invest Ophthalmol Vis Sci, 41, 2, pp. 362-368, (2000)

[5]

Kiziltoprak H, Tekin K, Inanc M, Goker YS., Cataract in diabetes mellitus, World J Diabetes, 10, 3, pp. 140-153, (2019)

[6]

Chen YY, Wu TT, Ho CY, Et al., Blocking of SGLT2 to eliminate NADPH-induced oxidative stress in lenses of animals with fructose-induced diabetes mellitus, Int J Mol Sci, 23, 13, (2022)

[7]

Vaiciuliene R, Rylskyte N, Baguzyte G, Jasinskas V., Risk factors for fluctuations in corneal endothelial cell density (Review), Exp Ther Med, 23, 2, (2022)

[8]

Govindaswamy S, Prabhakar S, Prabhakar S., Evaluation of antioxidative enzymes levels and lipid peroxidation products levels in diabetic and non diabetic senile cataract patients, J Diabetes Metab Disord, 21, 1, pp. 697-705, (2022)

[9]

Manikandan R, Thiagarajan R, Beulaja S, Sudhandiran G, Arumugam M., Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups, Curr Eye Res, 35, 2, pp. 122-129, (2010)

[10]

Olofsson EM, Marklund SL, Behndig A., Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice, Invest Ophthalmol Vis Sci, 50, 6, pp. 2913-2918, (2009)

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