Vitamin D and Neurological Health: Unraveling Risk Factors, Disease Progression, and Treatment Potential

被引:9
作者
Al Noman, Abdullah [1 ]
Afrosa, Halima [1 ]
Lihu, Imanul Kabir [1 ]
Sarkar, Onusree [1 ]
Nabin, Naimur Rahman [1 ]
Datta, Monty [2 ]
Pathak, Rashmi [3 ]
Sharma, Himanshu [4 ]
机构
[1] BRAC Univ, Sch Pharm, Dhaka, Bangladesh
[2] Natl Univ Bangladesh, Govt Tolaram Coll, Dept Zool, Gazipur 1704, Bangladesh
[3] Invertis Univ, Dept Biotechnol, Bareilly 243123, UP, India
[4] Teerthanker Mahaveer Univ, Teerthanker Mahaveer Coll Pharm, Moradabad 244001, UP, India
关键词
Vitamin D; neurology; gene regulation; neurological disorders; neuroprotection; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; PERIPHERAL NEUROPATHY; COGNITIVE FUNCTION; GENOME-WIDE; PREVENTION; SUPPLEMENTATION; DEMENTIA; PROMOTES;
D O I
10.2174/0118715273330972241009092828
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study explores the complex link between vitamin D and neurological illnesses, focusing on how vitamin D affects possible risk factors, therapeutic applications, and the trajectory of the disease. An epidemiological study has linked vitamin D insufficiency to several neurological conditions, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. It is hypothesized that immunomodulatory and anti-inflammatory properties of vitamin D contribute to its neuroprotective effects. Two major mechanisms in dementia include neuroinflammation and oxidative stress. Adequate levels of vitamin D have been shown in both animal models and human studies to enhance both clinical outcomes and the duration of illness in those who have it. Other ways that vitamin D contributes to its therapeutic potential include the production of neurotrophic factors, control over neurotransmitter synthesis, and preservation of the blood-brain barrier. Despite the encouraging outcomes, research is still being conducted to determine the optimal dosage and long-term benefits of vitamin D supplementation on brain function. In order to furnish precise directives and clarify the processes behind the neuroprotective impacts of vitamin D, future research must focus on large-scale randomized controlled studies. . This study highlights the significance of maintaining adequate levels of vitamin D as a modifiable risk factor for neurological disorders. Further study is also required to comprehend the possible medical benefits of this vitamin fully.
引用
收藏
页码:245 / 256
页数:12
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