Micro-RNAs targeting the estrogen receptor alpha involved in endocrine therapy resistance in breast cancer

被引：0
|
作者：
Marquez-Mendoza, J. M. [2 ]
Baranda-Avila, N. [1 ]
Lizano, M. [1 ,3 ]
Langley, E. [1 ]
机构：
[1] Inst Nacl Cancerol, Unidad Invest Biomed Canc, Subdirecc Invest Bas, Mexico City 14080, Mexico
[2] Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Biomed, Inst Invest Biomed, Ciudad Univ, Mexico City 04510, Mexico
[3] Univ Nacl Autonoma Mexico, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Ciudad Univ, Mexico City 04510, Mexico
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2025年 / 1871卷 / 05期
关键词：
Noncoding RNAs; micro-RNAs; Estrogen receptor alpha; Endocrine therapy resistance; Breast cancer; ENHANCES TAMOXIFEN RESISTANCE; ER-ALPHA; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATION; DIFFERENTIAL EXPRESSION; ANTIESTROGEN RESISTANCE; PROTEIN EXPRESSION; MIR-221; PROMOTES; DRUG-RESISTANCE; DOWN-REGULATION;
D O I：
10.1016/j.bbadis.2025.167783
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endocrine therapy resistance (ETR) in breast cancer (BC) is a multicausal phenomenon with diverse alterations in the tumor cell interactome. Within these alterations, non-coding RNAs (ncRNAs) such as micro-RNAs (miRNAs) modulate the expression of tumor suppressor genes and proto-oncogenes, such as the ESR1 gene encoding estrogen receptor alpha (ER alpha). This work aims to review the effects of miRNAs targeting ER alpha mRNA and their mechanisms related to ETR in BC. A thorough review of the literature and an in silico study were carried out to elucidate the involvement of each miRNA, thus contributing to the understanding of ETR in BC.
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页数：17
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