Genotoxic risks in patients with COVID-19

被引：0

作者：

Basaran, Nursen ^{[1
]}

Szewczyk-Roszczenko, Olga ^{[2
]}

Roszczenko, Piotr ^{[3
]}

Vassetzky, Yegor ^{[4
,5
]}

Sjakste, Nikolajs ^{[6
]}

机构：

[1] Baskent Univ, Fac Pharm, Dept Pharmaceut Toxicol, TR-06790 Ankara, Turkiye

[2] Med Univ Bialystok, Dept Synth & Technol Drugs, Bialystok, Poland

[3] Med Univ Bialystok, Dept Biotechnol, Bialystok, Poland

[4] Univ Paris Saclay, CNRS, Chromatin Dynam & Metab Canc, Inst Gustave Roussy,UMR9018, 39 Rue Camille Desmoulins, F-94805 Villejuif, France

[5] Russian Acad Sci, Koltzov Inst Dev Biol, Moscow 119334, Russia

[6] Univ Latvia, Fac Med & Life Sci, Jelgavas St 1, Riga, Latvia

来源：

INFECTION GENETICS AND EVOLUTION | 2025年 / 129卷

关键词：

COVID-19; SARS-CoV-2; DNA damage; Comet assay; Genotoxicity; DNA-DAMAGE; OXIDATIVE STRESS; REPAIR;

D O I：

10.1016/j.meegid.2025.105728

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The COVID-19 pandemic has caused numerous deaths worldwide. Despite the mitigation of infection manifestations in recent months, the possible consequences of the epidemic remain difficult to predict. Genotoxicity and subsequent development of neoplasms are possible outcomes. This review summarises the data on these questions. Studies from several countries have reported increased levels of DNA damage in nucleated blood cells of patients with severe forms of COVID-19 infection. The level of DNA damage can be used as a prognostic factor for the disease outcome. It is considered that SARS-CoV-2 spike proteins play a crucial role in DNA damage; however, the virus also inhibits the DNA repair system. Co-morbidities and use of antiviral drugs may also contribute to DNA damage in patients with COVID-19.

引用

页数：5

共 50 条

[1] Investigating DNA damage caused by COVID-19 and influenza in post COVID-19 [J].

Abiri, Elaheh ;

Mirzaii, Mehdi ;

Moghbeli, Majid ;

Atashi, Amir ;

Harati, Ahad Ali .

MAMMALIAN GENOME, 2025, 36 (01) :200-212

[2] Investigating the relationship between lymphocyte cells apoptosis and DNA damage and oxidative stress and therapeutic and clinical outcomes of COVID-19 elderly patients [J].

Abiri, Elaheh ;

Mirzaii, Mehdi ;

Moghbeli, Majid ;

Atashi, Amir ;

Harati, Ahad ali .

BMC INFECTIOUS DISEASES, 2024, 24 (01)

[3]

Basaran M.M., 2023, Oxidative Stress andImmune Responses. Toxics., V11, P386, DOI [10.3390/toxics11040386, DOI 10.3390/TOXICS11040386]

[4] Oxidative stress, DNA damage, and inflammation in COVID-19 patients [J].

Bektemur, Guven ;

Bozali, Kubra ;

Colak, Sahin ;

Aktas, Selman ;

Guler, Eray Metin .

NORTHERN CLINICS OF ISTANBUL, 2023, 10 (03) :335-340

[5] Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells [J].

Besaratinia, Ahmad ;

Caliri, Andrew W. ;

Tommasi, Stella .

DNA REPAIR, 2021, 106

[6] DNA damage and repair in type 2 diabetes mellitus [J].

Blasiak, J ;

Arabski, M ;

Krupa, R ;

Wozniak, K ;

Zadrozny, M ;

Kasznicki, J ;

Zurawska, M ;

Drzewoski, J .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 554 (1-2) :297-304

[7] DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death [J].

Bonassi, Stefano ;

Ceppi, Marcello ;

Moller, Peter ;

Azqueta, Amaya ;

Milic, Mirta ;

Monica, Neri ;

Brunborg, Gunnar ;

Godschalk, Roger ;

Koppen, Gudrun ;

Langie, Sabine A. S. ;

Teixeira, Joao Paulo ;

Bruzzone, Marco ;

Da Silva, Juliana ;

Benedetti, Danieli ;

Cavallo, Delia ;

Ursini, Cinzia Lucia ;

Giovannelli, Lisa ;

Moretti, Silvia ;

Riso, Patrizia ;

Del Bo', Cristian ;

Russo, Patrizia ;

Dobrzynska, Malgorzata ;

Goroshinskaya, Irina A. ;

Surikova, Ekaterina I. ;

Staruchova, Marta ;

Barancokova, Magdalena ;

Volkovova, Katarina ;

Kazimirova, Alena ;

Smolkova, Bozena ;

Laffon, Blanca ;

Valdiglesias, Vanessa ;

Pastor, Susana ;

Marcos, Ricard ;

Hernandez, Alba ;

Gajski, Goran ;

Spremo-Potparevic, Biljana ;

Zivkovic, Lada ;

Boutet-Robinet, Elisa ;

Perdry, Herve ;

Lebailly, Pierre ;

Perez, Carlos L. ;

Basaran, Nursen ;

Nemeth, Zsuzsanna ;

Safar, Anna ;

Dusinska, Maria ;

Collins, Andrew ;

Anderson, Diana ;

Andrade, Vanessa ;

Pereira, Cristiana Costa ;

Costa, Solange .

SCIENTIFIC REPORTS, 2021, 11 (01)

[8] Blood levels of nitric oxide and DNA breaks assayed in whole blood and isolated peripheral blood mononucleated cells in patients with multiple sclerosis [J].

Borisovs, Vitalijs ;

Leonova, Elina ;

Baumane, Larisa ;

Kalnina, Jolanta ;

Mjagkova, Natalja ;

Sjakste, Nikolajs .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2019, 843 :90-94

[9] DNA damage and its links to neuronal aging and degeneration [J].

Delint-Ramirez, Ilse ;

Madabhushi, Ram .

NEURON, 2025, 113 (01) :7-28

[10] SARS-CoV-2 infection reduces quality of sperm parameters: prospective one year follow-up study in 93 patients [J].

Depuydt, Christophe ;

Bosmans, Eugene ;

Jonckheere, Jef ;

Donders, Francesca ;

Ombelet, Willem ;

Coppens, Astrid ;

Donders, Gilbert .

EBIOMEDICINE, 2023, 93

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