Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy

被引：2

作者：

Henick, Brian S. ^{[1
,2
]}

Taylor, Alison M. ^{[1
,3
]}

Nakagawa, Hiroshi ^{[1
,4
]}

Wong, Kwok-Kin ^{[5
]}

Diehl, J. Alan ^{[6
]}

Rustgi, Anil K. ^{[1
,4
]}

机构：

[1] Columbia Univ, Vagelos Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Irving Med Ctr, New York, NY 10032 USA

[2] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, Div Hematol Oncol,Irving Med Ctr, New York, NY USA

[3] Columbia Univ, Vagelos Coll Phys & Surg, Dept Pathol & Cell Biol, Irving Med Ctr, New York, NY USA

[4] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, Div Digest & Liver Dis,Irving Med Ctr, New York, NY 10032 USA

[5] NYU, Dept Med, Div Hematol Oncol, Perlmutter Canc Ctr, New York, NY USA

[6] Case Western Reserve Comprehens Canc Ctr, Dept Biochem, Cleveland, OH USA

来源：

CANCER CELL | 2025年 / 43卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ESOPHAGEAL EPITHELIAL-CELLS; PATIENT-DERIVED XENOGRAFTS; GROWTH-FACTOR RECEPTOR; TUMOR-SUPPRESSOR; LUNG-CANCER; CYCLIN D1; NECK-CANCER; MOUSE MODEL; MUTANT P53; GENOMIC ANALYSIS;

D O I：

10.1016/j.ccell.2025.01.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Squamous cell cancers (SCCs) of the head and neck, esophagus, and lung, referred to as aero-upper digestive SCCs, are prevalent in the United States and worldwide. Their incidence and mortality are projected to increase at alarming rates, posing diagnostic, prognostic, and therapeutic challenges. These SCCs share certain epigenetic, genomic, and genetic alterations, immunologic properties, environmental exposures, as well as lifestyle and nutritional risk factors, which may underscore common complex gene-environmental interactions across them. This review focuses upon the frequent shared epigenetic, genomic, and genetic alterations, emerging preclinical model systems, and how this collective knowledge can be leveraged into perspectives on standard of care therapies and mechanisms of resistance, nominating new potential directions in translational therapeutics.

引用

页码：178 / 194

页数：17

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