Genetic Overlap Between Obstructive Sleep Apnea and Ischemic Stroke: A Large-Scale Genome-Wide Cross-Trait Analysis

被引：0
作者：
Lin, Wanqing [1 ,2 ,3 ]
Zhang, Zhiyi [4 ]
Wang, Chenlin [5 ]
Ye, Yingling [5 ]
Zheng, Lingrong [5 ]
Hu, Qianqian [5 ]
Yu, Renyu [1 ,2 ]
Wu, Mingxia [5 ,6 ]
Chen, Bin [1 ,2 ]
机构：
[1] Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp, Dept Rehabil Med, Fuzhou 350004, Fujian, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp, Natl Clin Res Base Tradit Chinese Med, Fuzhou 350004, Fujian, Peoples R China
[3] Fujian Univ Tradit Chinese Med, Affiliated Rehabil Hosp, Fuzhou 350003, Fujian, Peoples R China
[4] Quanzhou Orthoped Traumatol Hosp, Dept Massage, Quanzhou 362000, Fujian, Peoples R China
[5] Fujian Univ Tradit Chinese Med, Fuzhou 350122, Fujian, Peoples R China
[6] Fujian Univ Chinese Med, Peoples Hosp 2, Fuzhou 350001, Fujian, Peoples R China
来源：
NATURE AND SCIENCE OF SLEEP | 2025年 / 17卷
基金：
中国国家自然科学基金;
关键词：
obstructive sleep apnea; ischemic stroke; GWAS; genetic overlap; CARDIOVASCULAR-DISEASE; RISK-FACTOR; METAANALYSIS; ASSOCIATION; MECHANISMS; MORTALITY; AUTOPHAGY; PRESSURE; FOXF2;
D O I：
10.2147/NSS.S495422
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: To further understand the complex relationship between Obstructive Sleep Apnea (OSA) and ischemic stroke, this study explores the role of genetic factors in the comorbidity of these two conditions. Methods: Based on large-scale available Genome-Wide Association Studies (GWAS) for OSA and ischemic stroke, we conducted a multi-level cross-trait analysis. First, we utilized Linkage Disequilibrium Score Regression (LDSC) to analyze the genetic correlation between the two diseases. Subsequently, we performed cross-trait analysis to identify pleiotropic Single Nucleotide Polymorphisms (SNPs) associated with both OSA and ischemic stroke. On this basis, we applied annotation and Multi-marker Analysis of GenoMic Annotation (MAGMA) analysis to examine results at the gene level. Finally, we conducted Transcriptome-Wide Association Studies (TWAS) to analyze gene expressions significantly related to both traits. Results: The LDSC analysis revealed a significant positive genetic correlation between OSA and ischemic stroke. Cross-trait analysis identified a total of 90 pleiotropic SNPs, with rs78581380 being the most significant. Combining Functional Mapping and Annotation (FUMA) annotation and MAGMA analysis, we identified 83 genes in total. TWAS analysis discovered 23 gene expressions that were significantly associated with both OSA and ischemic stroke traits. Conclusion: This study elucidates the shared genetic architecture between OSA and ischemic stroke, emphasizing the crucial role of genetic factors in the comorbidity of these two conditions.
引用
收藏
页码：413 / 424
页数：12
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