Age-Dependent DNA Methylation Variability on the X-Chromosome in Male and Female Twins

被引：0

作者：

Tan, Qihua ^{[1
,2
]}

Alo, Hikmat ^{[1
]}

Nygaard, Marianne ^{[1
]}

Sorensen, Mette ^{[1
]}

Saleh, Alisa ^{[1
]}

Mengel-From, Jonas ^{[1
]}

Christensen, Kaare ^{[1
]}

机构：

[1] Univ Southern Denmark, Dept Publ Hlth, Epidemiol Biostat & Biodemog, Campusvej 55, DK-5230 Odense, Denmark

[2] Univ Southern Denmark, Dept Clin Res, Unit Human Genet, Campusvej 55, DK-5230 Odense, Denmark

来源：

EPIGENOMES | 2024年 / 8卷 / 04期

关键词：

epigenetic instability; X-linked DNA methylation; aging; twins; mortality; EPIGENETIC DRIFT;

D O I：

10.3390/epigenomes8040043

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We aimed to explore the age-dependent epigenetic variability on the X-chromosome with consideration of X-chromosome inactivation by applying a sex-stratified regression analysis to DNA methylation array data on X-linked CpGs in aging identical twins. We found 13 X-linked CpGs showing age-related significant increase in variability in males (FDR < 0.05) but none in females. In females, we found a significantly higher proportion of CpGs showing increased variability with age among nominally significant (p < 0.05) CpGs under inactivation, but not among CpGs escaping inactivation. Survival analysis showed a slight trend of correlation by directional change in the variable CpGs with mortality in males. Compared with females, the male X-chromosome can be more vulnerable to epigenetic instability during aging.

引用

页数：10

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