Hypermonethers A and B, two highly oxidized monoprenylated diphenyl ethers from Hypericum monogynum

被引：0

作者：

Zhang, Tailong ^{[1
]}

Wei, Jiangchun ^{[2
,3
]}

Jin, Xingpiao ^{[2
]}

Hu, Zhengxi ^{[2
,4
]}

Geng, Bingchuan ^{[1
]}

Dong, Nianguo ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[3] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Shenzhen 518035, Peoples R China

[4] Hubei Shizhen Lab, Wuhan 430061, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2025年 / 65卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Hypericum monogynum; Diphenyl ethers; Structural elucidation; Calcific aortic valve disease; AORTIC-VALVE DISEASE;

D O I：

10.1016/j.phytol.2024.12.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Hypermonethers A (1) and B (2), two highly oxidized monoprenylated diphenyl ethers, were isolated from the petroleum ether extract of Hypericum monogynum. Their structures were elucidated by the comprehensive spectroscopic analyses and optical rotation (OR) calculation. Compounds 1 and 2 represent the first examples of diphenyl ethers with a prenyl side chain. Our bioassays have revealed that hypermonether B (HPB, 2) displayed significant inhibitory effect on the osteogenic differentiation of human valvular interstitial cells, highlighting its potential as a preventive agent against the progression of human calcific aortic valve disease (CAVD).

引用

页码：77 / 81

页数：5

共 5 条

[1] Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum
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TETRAHEDRON LETTERS, 2021, 64
[2] Functional characterization of a Flavonol 3-O-rhamnosyltransferase and two UDP-rhamnose synthases from Hypericum monogynum
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[3] Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity
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PHYTOCHEMISTRY LETTERS, 2015, 13 : 286 - 289
[4] Diorcinols B-E, new prenylated diphenyl ethers from the marine-derived fungus Aspergillus versicolor ZLN-60
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[5] Diorcinols B-E, new prenylated diphenyl ethers from the marine-derived fungus Aspergillus versicolor ZLN-60
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Zhou, Lina
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