Nanocellulose/Graphene Oxide Composite Beads as a Novel Hemoperfusion Adsorbent for Efficient Removal of Bilirubin Plasma

被引:0
作者
Wei, Xuanru [1 ]
Zhu, Hengfeng [1 ,2 ]
Hong, Dichan [2 ]
Li, Xiangxian [2 ]
Shi, Zhuqun [1 ,2 ]
Yang, Quanling [2 ]
机构
[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China
[2] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China
关键词
GRAPHENE OXIDE; CELLULOSE; ADSORPTION; BLOOD; HYDROGEL; CONSTRUCTION; HEMOFILTRATION; TRANSPARENT; FABRICATION; NANOFIBERS;
D O I
10.1021/acs.biomac.4c01838
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Conventional hemoperfusion adsorbents suffer from inefficiency and poor biocompatibility. Cellulose, a natural polysaccharide with biocompatible, biodegradable, and nontoxic properties, was combined with graphene oxide (GO) to fabricate composite beads (TGO) for blood purification. GO synthesized via a modified Hummers method was complexed with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibrils (TOCNs). Increasing GO content (2-20 wt %) enhanced TGO's specific surface area (256.4-289.0 m(2) g(-1)) while retaining an similar to 10 nm pore size. TGO demonstrated exceptional adsorption capacities: bilirubin (418.4 mg g(-1)), creatinine (23.5 mg g(-1)), uric acid (146.6 mg g(-1)), and Cu2+ (171.9 mg g(-1)). The beads exhibited excellent hemocompatibility (hemolysis rate <5%) and prolonged recalcification time (585 +/- 5.2 s). Notably, TGO restored blood bilirubin levels to normal within 30 min, highlighting its potential for blood purification.
引用
收藏
页码:2458 / 2466
页数:9
相关论文
共 65 条
[1]   Graphene oxide modified thiosemicarbazide nanocomposite as an effective eliminator for heavy metal ions [J].
Abubshait, Haya A. ;
Farag, Ahmed A. ;
El-Raouf, Mohamed A. ;
Negm, Nabel A. ;
Mohamed, Eslam A. .
JOURNAL OF MOLECULAR LIQUIDS, 2021, 327
[2]   Preparation of porous carbon nanotube/carbon composite spheres and their adsorption properties [J].
Bai, Junfei ;
Huang, Yilun ;
Gong, Qianming ;
Liu, Xi ;
Li, Yuyao ;
Gan, Jianning ;
Zhao, Ming ;
Shao, Yang ;
Zhuang, Daming ;
Liang, Ji .
CARBON, 2018, 137 :493-501
[3]   COVID-19 Government Response Event Dataset (CoronaNet v.1.0) [J].
Cheng, Cindy ;
Barcelo, Joan ;
Hartnett, Allison Spencer ;
Kubinec, Robert ;
Messerschmidt, Luca .
NATURE HUMAN BEHAVIOUR, 2020, 4 (07) :756-+
[4]   Nanocellulose Hydrogel for Blood Typing Tests [J].
Curvello, Rodrigo ;
Mendoza, Llyza ;
McLiesh, Heather ;
Manolios, Jim ;
Tabor, Rico F. ;
Garnier, Gil .
ACS APPLIED BIO MATERIALS, 2019, 2 (06) :2355-2364
[5]   Evolving Trends in Machine Perfusion for Liver Transplantation [J].
Dutkowski, Phillipp ;
Guarrera, James V. ;
De Jonge, Jeroen ;
Martins, Paulo N. ;
Porte, Robert J. ;
Clavien, Pierre-Alain .
GASTROENTEROLOGY, 2019, 156 (06) :1542-1547
[6]   Graphene oxide/alginate/silk fibroin composite as a novel bionanostructure with improved blood compatibility, less toxicity and enhanced mechanical properties [J].
Eivazzadeh-Keihan, Reza ;
Radinekiyan, Fateme ;
Madanchi, Hamid ;
Aliabadi, Hooman Aghamirza Moghim ;
Maleki, Ali .
CARBOHYDRATE POLYMERS, 2020, 248
[7]   Nanocellulose composite wound dressings for real-time pH wound monitoring [J].
Eskilson, Olof ;
Zattarin, Elisa ;
Berglund, Linn ;
Oksman, Kristiina ;
Hanna, Kristina ;
Rakar, Jonathan ;
Sivler, Petter ;
Skog, Marten ;
Rinklake, Ivana ;
Shamasha, Rozalin ;
Sotra, Zeljana ;
Starkenberg, Annika ;
Oden, Magnus ;
Wiman, Emanuel ;
Khalaf, Hazem ;
Bengtsson, Torbjorn ;
Junker, Johan P. E. ;
Selegard, Robert ;
Bjork, Emma M. ;
Aili, Daniel .
MATERIALS TODAY BIO, 2023, 19
[8]   Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties [J].
Fernandez, Katherina ;
Llanquileo, Aylen ;
Bustos, Monserrat ;
Aedo, Valentina ;
Ruiz, Isleidy ;
Carrasco, Sebastian ;
Tapia, Mauricio ;
Pereira, Miguel ;
Melendrez, Manuel F. ;
Aguayo, Claudio ;
Atanase, Leonard I. .
POLYMERS, 2023, 15 (12)
[9]   MOFs-alginate/polyacrylic acid/poly (ethylene imine) heparin-mimicking beads as a novel hemoadsorbent for bilirubin removal in vitro and vivo models [J].
Gan, Na ;
Sun, Qiaomei ;
Peng, Xu ;
Ai, Pu ;
Wu, Di ;
Yi, Bin ;
Xia, Haobin ;
Wang, Xinlong ;
Li, Hui .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 235
[10]   Adsorption and removal of tetracycline antibiotics from aqueous solution by graphene oxide [J].
Gao, Yuan ;
Li, Yan ;
Zhang, Liang ;
Huang, Hui ;
Hu, Junjie ;
Shah, Syed Mazhar ;
Su, Xingguang .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2012, 368 :540-546