Targeting Mitochondrial Metabolism to Promote Viral Mimicry and Type I Interferon Response in Acute Myeloid Leukemia

被引:0
|
作者
Balasundaram, Nithya [1 ]
Andreas, Hernan Tirado [1 ]
Leguay, Fleur [1 ]
Van Gastel, Nick [1 ]
机构
[1] UC Louvain, De Duve Inst, Lab Cellular Metab & Microenvironm, Brussels, Belgium
关键词
D O I
10.1182/blood-2024-210257
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:827 / 828
页数:2
相关论文
共 50 条
  • [21] Disruption of mitochondrial metabolism underlies the efficacy of devimistat in acute myeloid leukemia
    Reid, Michael A.
    Bose, Shree
    Xiao, Zhengtao
    Mikhael, Peter G.
    Liu, Juan
    Locasale, Jason W.
    Pardee, Timothy S.
    CANCER RESEARCH, 2020, 80 (16)
  • [22] Pkcε Is a Central Regulator of Mitochondrial Function and Metabolism in Acute Myeloid Leukemia
    Di Marcantonio, Daniela
    Masselli, Elena
    Martinez, Esteban
    Araiza-Olivera, Daniela
    Gobbi, Giuliana
    Mirandola, Prisco
    Vitale, Marco
    Sykes, Stephen M.
    BLOOD, 2018, 132
  • [23] Type I mutations in pediatric acute myeloid leukemia
    Goemans, B. F.
    Zwaan, Ch. M.
    Cloos, J.
    Kaspers, G. J. L.
    ANNALS OF HEMATOLOGY, 2008, 87 : S62 - S64
  • [24] PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing
    Kissig, Megan
    Ishibashi, Jeff
    Harms, Matthew J.
    Lim, Hee-Woong
    Stine, Rachel R.
    Won, Kyoung-Jae
    Seale, Patrick
    EMBO JOURNAL, 2017, 36 (11): : 1528 - 1542
  • [25] Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia
    Chen, Xiufen
    Fosco, Dominick
    Kline, Douglas E.
    Kline, Justin
    ONCOIMMUNOLOGY, 2017, 6 (04):
  • [26] Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium
    Sheth, Anagha Inguva
    Althoff, Mark J.
    Tolison, Hunter
    Engel, Krysta
    Amaya, Maria L.
    Krug, Anna E.
    Young, Tracy N.
    Minhajuddin, Mohammad
    Pei, Shanshan
    Patel, Sweta B.
    Winters, Amanda
    Miller, Regan
    Shelton, Ian T.
    St-Germain, Jonathan
    Ling, Tianyi
    Jones, Courtney L.
    Raught, Brian
    Gillen, Austin E.
    Ransom, Monica
    Staggs, Sarah
    Smith, Clayton A.
    Pollyea, Daniel A.
    Stevens, Brett M.
    Jordan, Craig T.
    CANCER DISCOVERY, 2024, 14 (10) : 1922 - 1939
  • [27] Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism
    Baran, Natalia
    Han, Lina
    Stuani, Lucille
    Cavazos, Antonio
    Cooper, Laurie
    Ramage, Cassandra L.
    Kuruvilla, Vinitha Mary
    Zhang, Qi
    Sabtier, Marie
    Boet, Emeline
    Gay, Jason P.
    Feng, Ninping
    Battula, Venkata Lokesh
    Chu-Van, Emeline
    Castelli, Florence
    Carroll, Martin
    Konoplev, Sergej Naumovich
    Thakral, Beenu
    Daver, Naval
    Marszalek, Joseph R.
    Ge, Yubin
    Andreeff, Michael
    Sarry, Jean-Emmanuel
    Konopleva, Marina Y.
    BLOOD, 2023, 142
  • [28] Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response
    Marina Scheller
    Anne Kathrin Ludwig
    Stefanie Göllner
    Christian Rohde
    Stephen Krämer
    Sina Stäble
    Maike Janssen
    James-Arne Müller
    Lixiazi He
    Nicole Bäumer
    Christian Arnold
    Joachim Gerß
    Maximilian Schönung
    Christian Thiede
    Christian Niederwieser
    Dietger Niederwieser
    Hubert Serve
    Wolfgang E. Berdel
    Ulrich Thiem
    Inga Hemmerling
    Florian Leuschner
    Christoph Plass
    Matthias Schlesner
    Judith Zaugg
    Michael D. Milsom
    Andreas Trumpp
    Caroline Pabst
    Daniel B. Lipka
    Carsten Müller-Tidow
    Nature Cancer, 2021, 2 : 527 - 544
  • [29] Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response
    Scheller, Marina
    Ludwig, Anne Kathrin
    Goellner, Stefanie
    Rohde, Christian
    Kraemer, Stephen
    Staeble, Sina
    Janssen, Maike
    Mueller, James-Arne
    He, Lixiazi
    Baumer, Nicole
    Arnold, Christian
    Gerss, Joachim
    Schoenung, Maximilian
    Thiede, Christian
    Niederwieser, Christian
    Niederwieser, Dietger
    Serve, Hubert
    Berdel, Wolfgang E.
    Thiem, Ulrich
    Hemmerling, Inga
    Leuschner, Florian
    Plass, Christoph
    Schlesner, Matthias
    Zaugg, Judith
    Milsom, Michael D.
    Trumpp, Andreas
    Pabst, Caroline
    Lipka, Daniel B.
    Muller-Tidow, Carsten
    NATURE CANCER, 2021, 2 (05) : 527 - +
  • [30] The host type I interferon response to viral and bacterial infections
    Andrea K. PERRY
    CellResearch, 2005, (06) : 407 - 422