Associations Between Chronic Rhinosinusitis and the Development of Non-Cystic Fibrosis Bronchiectasis

被引：3

作者：

Kim, So Lim ^{[1
]}

Schwartz, Brian S. ^{[2
,3
]}

Vu, Thanh-Huyen ^{[4
]}

Conley, David B. ^{[5
]}

Grammer, Leslie C. ^{[1
]}

Guo, Amina ^{[1
]}

Kato, Atsushi ^{[1
]}

Kern, Robert C. ^{[5
]}

Prickett, Michelle H. ^{[6
]}

Schleimer, Robert P. ^{[1
,5
]}

Smith, Stephanie ^{[5
]}

Stevens, Whitney W. ^{[1
]}

Suh, Lydia ^{[1
]}

Tan, Bruce K. ^{[5
]}

Welch, Kevin C. ^{[5
]}

Peters, Anju T. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Allergy & Immunol, 211 E Ontario St,Suite 1000, Chicago, IL 60611 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth & Engn, Baltimore, MD USA

[3] Geisinger, Dept Populat Hlth Sci, Danville, PA USA

[4] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Div Epidemiol, Chicago, IL USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol Head & Neck Surg, Chicago, IL USA

[6] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Pulm & Crit Care, Chicago, IL USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2024年 / 12卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Chronic rhinosinusitis; Non- cystic fi brosis bronchiectasis; UNITED AIRWAYS; NASAL POLYPS; PREVALENCE;

D O I：

10.1016/j.jaip.2024.07.027

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: Studies have shown an association between chronic rhinosinusitis (CRS) and non- cystic fi brosis (CF) bronchiectasis. OBJECTIVE: We aimed to determine whether CRS increases the risk of developing non-CF bronchiectasis. METHODS: A retrospective analysis was conducted utilizing electronic medical records from an academic center. Patients with CRS without bronchiectasis, with at least 1 chest computed tomography (CT) scan performed after the diagnosis of CRS, were identified between January 2006 and December 2015. Charts were reviewed until May 2022. The control group was age-, sex-, and race-matched, and included patients without CRS, asthma, or chronic obstructive pulmonary disease (COPD) who had at least 1 chest CT scan. Bronchiectasis was identified by chest CT radiology reports. The odds of developing bronchiectasis were analyzed in patients with CRS without asthma or COPD (cohort 1) and patients with CRS with asthma or COPD (cohort 2). RESULTS: The odds of developing bronchiectasis were significantly higher in patients with CRS (139 of 1,594; 8.7%) than in patients in the control group (443 of 7,992; 5.5%; odds ratio OR 1.63; 95% confidence interval [95% CI] 1.34-1.99). Furthermore, the odds of developing bronchiectasis were higher in cohort 1 (63 of 863; 7.3%; OR 1.34; 05% CI 1.02-1.76) and cohort 2 (76/ of 731; 10.4%; OR 1.98; 95% CI 1.53-2.55) versus the control group. After adjusting for confounding diseases, the association was attenuated in cohort 1 (OR 1.22; 95% CI 0.92-1.61) but remained significant in cohort 2 (OR 1.78; 95% CI 1.37-2.31). CONCLUSIONS: The CRS is associated with the future development of non-CF bronchiectasis. Patients with CRS, especially those with asthma or COPD, have a higher likelihood of developing bronchiectasis than patients without CRS. (c) 2024 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2024;12:3116-22)

引用

页码：3116 / 3122.e2

页数：9