Epidemiology, incidence, and outcome of childhood cancers in the Afro-descendant population of the French West Indies and French Guiana: a population-based study

被引：0

作者：

Dichamp, Claire ^{[1
]}

Lacour, Brigitte ^{[2
,3
]}

Clavel, Jacqueline ^{[2
,3
]}

Dalle, Jean-Hugues ^{[4
]}

Dufour, Christelle ^{[5
]}

Michaux, Katell ^{[1
]}

Puget, Stephanie ^{[6
]}

Faivre, Benjamin ^{[7
]}

Delion, Frederique ^{[8
]}

Aigoun, Nadjia ^{[9
]}

Hatchuel, Yves

Mascle, Julie

Denailly, Helene ^{[7
]}

Petit, Arnaud ^{[10
]}

Leverger, Guy ^{[10
]}

Orbach, Daniel ^{[11
]}

Berry, Juliette ^{[11
]}

Boissel, Nicolas ^{[12
,13
]}

Raimondo, Graziella ^{[14
]}

Sarnacki, Sabine ^{[15
]}

Cousin, Ianis ^{[16
]}

Drame, Moustapha ^{[17
,18
]}

Baruchel, Andre ^{[4
]}

Minard-Colin, Veronique ^{[5
]}

Felix, Arthur ^{[1
,18
]}

机构：

[1] Univ Hosp Ft de France, Dept Pediat, Children Hematol & Oncol Unit, Fort De France, Martinique, France

[2] CHU Paul Brousse, French Natl Registry Childhood Canc, RNHE, AP HP, Villejuif, France

[3] CHU Nancy, RNTSE, Nancy, France

[4] Univ Hosp Robert Debre, AP HP, Dept Pediat Hematol & Immunol, Paris, France

[5] Univ Paris Saclay, Inst Gustave Roussy, Dept Pediat & Adolescent Oncol, Villejuif, France

[6] Univ Hosp Ft De France, Dept Neurosurg, Fort De France, Martinique, France

[7] Hosp Cayenne, Dept Pediat, Cayenne, French Guiana, France

[8] Univ Hosp Pointe A Pitre, Dept Pediat, Guadeloupe, France

[9] Ctr Hosp Ouest Guyanais, Dept Pediat, St Laurent Du Maroni, France

[10] Trousseau Hosp, AP HP, Pediat Hematol & Oncol Dept, F-75012 Paris, France

[11] PSL Univ, Inst Curie, SIREDO Oncol Ctr Care Innovat & Res Children, Adolescents & Young Adults Canc, Paris, France

[12] St Louis Hosp, AP HP, Hematol Adolescent & Young Adult Unit, Paris, France

[13] Univ Paris, Inst Rech St Louis, URP 3518, Paris, France

[14] Croix Rouge Hosp Margency, Dept Pediat, Margency, France

[15] Univ Paris Cite, Hop Univ Necker Enfants Malad, AP HP, Dept Pediat Surg Urol & Transplantat, Paris, France

[16] Univ Hosp Ft De France, Dept Pediat Surg, Fort De France, Martinique, France

[17] Martinique Univ Hosp, Dept Clin Res & Innovat, Fort De France, France

[18] Univ French West Indies, Univ Hosp Fort De France, EpiCliV Res Unit, Fort De France, Martinique, France

来源：

LANCET REGIONAL HEALTH-AMERICAS | 2025年 / 44卷

关键词：

Childhood cancer; Epidemiology; Incidence; Survival; Afro-Caribbean children; CHLORDECONE EXPOSURE; RACIAL DISPARITIES; ADOLESCENT CANCER; CHILDREN; SURVIVAL; MORTALITY; LEUKEMIA; FRANCE;

D O I：

10.1016/j.lana.2025.101050

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background The epidemiology of childhood cancer in Afro-descendant (AD) populations is poorly described. We performed a descriptive study of the distribution, incidence, and survival of children with cancer in the French West Indies (FWI) and French Guiana (FG). Methods We included all patients aged 0-17 diagnosed with cancer or benign intracranial tumor between January 2011 and December 2021 and living in the FWI/FG area at time of diagnosis. The cases were identified from the French national registry of childhood cancer and cross-referenced with local sources. Incidence rates were calculated, and compared to that of mainland France by standardized incidence ratios (SIR). Vital status was completed up to the 31st of December 2023 (date of point). Relapses were identified and documented in pediatric reference centers in mainland France and local centers. The 5-year overall survival (5yOS) and event-free survival (5yEFS) were estimated using Kaplan-Meier method. Findings We identified 368 patients (26% leukemias, 21% central nervous system tumors, 12% lymphomas, and 41% others). The average age at diagnosis was 8.8 years (Range: 0.1-17.8), with 52% boys. The median follow-up was 4.4 years (Range: 0.1-12.3). The age standardized rates for all cancers was lower than in mainland France (124.9 vs 162.6 per million-year for children under 18 years old, SIR = 0.77 [95% CI: 0.69-0.85]). The 5yOS was 78.9% [95% CI: 73.9-83.0] and 5yEFS was 69.3% [95% CI: 63.9-74.0]. The 5yOS for the 0-14 age group was 81.2% [95% CI: 76.9-85.5]. Interpretation This first registry-based study of childhood cancer in the FWI and FG shows that our patients with childhood cancer, treated in a country with a high standard of health care, has resulted in overall survival comparable to that of European and North American children. Funding The authors received no financial support. Copyright (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：11

共 39 条

[1] Lacour B., Goujon S., Guissou S., Et al., Childhood cancer survival in France, 2000-2008, Eur J Cancer Prev, 23, 5, pp. 449-457, (2014)
[2] Lacour B., Guyot-Goubin A., Guissou S., Bellec S., Desandes E., Clavel J., Incidence of childhood cancer in France: National Children Cancer Registries, 2000–2004, Eur J Cancer Prev, 19, 3, pp. 173-181, (2010)
[3] Goujon S., Kyrimi E., Faure L., Et al., Spatial and temporal variations of childhood cancers: literature review and contribution of the French national registry, Cancer Med, 7, 10, pp. 5299-5314, (2018)
[4] Castellanos M.I., Dongarwar D., Wanser R., Et al., In-hospital mortality and racial disparity in children and adolescents with acute myeloid leukemia: a population-based study, J Pediatr Hematol Oncol, 44, 1, pp. e114-e122, (2022)
[5] Mitchell H.K., Morris M., Ellis L., Abrahao R., Bonaventure A., Racial/ethnic and socioeconomic survival disparities for children and adolescents with central nervous system tumours in the United States, 2000-2015, Cancer Epidemiol, 64, (2020)
[6] Holmes L., Williams M.A., Halloran D.R., Et al., Social gradient predicts survival disadvantage of African Americans/Black children with lymphoma, J Natl Med Assoc, 113, 4, pp. 414-427, (2021)
[7] Kahn J.M., Kelly K.M., Pei Q., Et al., Survival by race and ethnicity in pediatric and adolescent patients with Hodgkin lymphoma: a children's oncology group study, J Clin Oncol, 37, 32, pp. 3009-3017, (2019)
[8] Felix A., Dichamp C., Michaux K., Et al., Afro-descendant ethnicity does not negatively influence neuroblastoma survival in the French West Indies, Pediatr Blood Cancer, 71, 8, (2024)
[9] Felix A., Delion F., Suzon B., Et al., Systemic juvenile idiopathic arthritis in French Afro-Caribbean children, a retrospective cohort study, Pediatr Rheumatol Online J, 20, 1, (2022)
[10] Levinson D., Ethnic Groups Worldwide: A Ready Reference Handbook, (1998)

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