The NEMO/ATM/IKKα complex: A key player in colorectal cancer progression and treatment

被引：0

作者：

Perkins, Neil D. ^{[1
]}

机构：

[1] Newcastle Univ, Biosci Inst, Fac Med Sci, NEWCASTLE UPON TYNE NE1 7RU, England

来源：

SCIENCE SIGNALING | 2025年 / 18卷 / 877期

关键词：

IKK-ALPHA;

D O I：

10.1126/scisignal.adv1265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The kinase IKK alpha phosphorylates the kinase ATM, enhancing its ability to promote DNA repair. In this issue of Science Signaling, Alonso-Mara & ntilde;& oacute;n et al. demonstrate that in colorectal cancer cells, the IKK regulatory subunit NEMO targets the ATM/IKK alpha complex to sites of DNA damage, thus enhancing DNA repair and chemotherapy resistance.

引用

页数：2