The NEMO/ATM/IKKα complex: A key player in colorectal cancer progression and treatment

被引：0
|
作者：
Perkins, Neil D. [1 ]
机构：
[1] Newcastle Univ, Biosci Inst, Fac Med Sci, NEWCASTLE UPON TYNE NE1 7RU, England
来源：
SCIENCE SIGNALING | 2025年 / 18卷 / 877期
关键词：
IKK-ALPHA;
D O I：
10.1126/scisignal.adv1265
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The kinase IKK alpha phosphorylates the kinase ATM, enhancing its ability to promote DNA repair. In this issue of Science Signaling, Alonso-Mara & ntilde;& oacute;n et al. demonstrate that in colorectal cancer cells, the IKK regulatory subunit NEMO targets the ATM/IKK alpha complex to sites of DNA damage, thus enhancing DNA repair and chemotherapy resistance.
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