Terahertz biosensor supported by quasi-bound states in the continuum for lung cancer cell sensing

We design a terahertz (THz) biosensor supported by quasi-bound states in the continuum (QBICs) for lung cancer cell sensing. By destroying the in-plane symmetry of the bound state in the continuum (BIC), a QBIC with a high Q-factor is obtained. The designed biosensor exhibits excellent refractive index performance with a sensitivity of 354 GHZ/RIU. Unlike traditional detection schemes that require sample drying, a microfluidic liquid sample pool is utilized to detect different concentrations of lung cancer cells. As the cell concentration increases, the resonance frequency and intensity of the measured spectrum show significant changes. The designed sensor allows non-invasive real-time detection of living lung cancer cells, providing a potentially effective tool for early diagnosis and treatment of lung cancer.