The role of cGAS-STING signaling in rheumatoid arthritis: from pathogenesis to therapeutic targets

被引:3
作者
Zhu, Qiugang [1 ]
Zhou, Huimin [2 ]
机构
[1] Shaoxing Univ, Shangyu Peoples Hosp Shaoxing, Dept Lab Med, Shaoxing, Peoples R China
[2] Soochow Univ, Wuxi Affiliated Hosp 9, Dept Lab Med, Wuxi, Peoples R China
关键词
rheumatoid arthritis; cGAS; STING; signaling pathway; treatments; GMP-AMP SYNTHASE; ANTIMALARIAL-DRUGS; I INTERFERONS; DNA; PATHWAY; HYDROXYCHLOROQUINE; ACTIVATION; MECHANISMS; SENSOR;
D O I
10.3389/fimmu.2024.1466023
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily characterized by erosive and symmetric polyarthritis. As a pivotal axis in the regulation of type I interferon (IFN-I) and innate immunity, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has been implicated in the pathogenesis of RA. This pathway mainly functions by regulating cell survival, pyroptosis, migration, and invasion. Therefore, understanding the sources of cell-free DNA and the mechanisms underlying the activation and regulation of cGAS-STING signaling in RA offers a promising avenue for targeted therapies. Early detection and interventions targeting the cGAS-STING signaling are important for reducing the medical burden on individuals and healthcare systems. Herein, we review the existing literature pertaining to the role of cGAS-STING signaling in RA, and discuss current applications and future directions for targeting the cGAS-STING signaling in RA treatments.
引用
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页数:12
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