The involvement of the microbiota-gut-brain axis in the pathophysiology of mood disorders and therapeutic implications

被引：4

作者：

Barbosa, Izabela G. ^{[1
,2
,3
]}

Miranda, Aline S. ^{[2
,3
,4
]}

Berk, Michael ^{[5
]}

Teixeira, Antonio L. ^{[6
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Fac Med, Dept Psiquiatr, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Programa Posgrad Neurociencias, Inst Ciencias Biol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais UFMG, Fac Med, Lab Interdisciplinar Invest Med, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Dept Morfol, Lab Neurobiol, Inst Ciencias Biol, Belo Horizonte, MG, Brazil

[5] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, IMPACT, Geelong, Australia

[6] Univ Texas Hlth Sci Ctr San Antonio, Biggs Inst Alzheimers & Neurodegenerat Dis, Neuropsychiat Div, San Antonio, TX USA

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2025年 / 25卷 / 01期

关键词：

Mood disorder; depression; bipolar disorder; microbiota; mental health; psychiatry; Brain-gut axis; OXIDATIVE STRESS; BIPOLAR; DEPRESSION; OMEGA-3-FATTY-ACIDS; IMPACT; SCHIZOPHRENIA; ABNORMALITIES; ARIPIPRAZOLE; EXPRESSION; SYMPTOMS;

D O I：

10.1080/14737175.2024.2438646

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionThere is a growing body of evidence implicating gut-brain axis dysfunction in the pathophysiology of mood disorders. Accordingly, gut microbiota has become a promising target for the development of biomarkers and novel therapeutics for bipolar and depressive disorders.Areas coveredWe describe the observed changes in the gut microbiota of patients with mood disorders and discuss the available studies assessing microbiota-based strategies for their treatment.Expert opinionMicrobiota-targeted interventions, such as symbiotics, prebiotics, paraprobiotics, and fecal microbiota transplants seem to attenuate the severity of depressive symptoms. The available results must be seen as preliminary and need to be replicated and/or confirmed in larger and independent studies, also considering the pathophysiological and clinical heterogeneity of mood disorders.

引用

页码：85 / 99

页数：15

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