Impact of the gut microbiota-Th17 cell axis on inflammatory depression

被引：1

作者：

Jia, Xiuzhi ^{[1
,2
]}

Wang, Jiayi ^{[2
]}

Ren, Dan ^{[2
]}

Zhang, Kaibo ^{[1
]}

Zhang, Hongliang ^{[2
]}

Jin, Tengchuan ^{[2
,3
]}

Wu, Songquan ^{[1
,2
]}

机构：

[1] Lishui Univ, Coll Med, Dept Immunol & Pathogen Biol, Lishui 323000, Zhejiang, Peoples R China

[2] Lishui Univ, Coll Med, Ctr Dis Immun & Intervent, Lishui 323000, Peoples R China

[3] Univ Sci & Technol China USTC, Div Life Sci & Med, Lab Struct Immunol, Hefei, Anhui, Peoples R China

来源：

FRONTIERS IN PSYCHIATRY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

depression; interleukin-17; T-helper; 17; cells; gut microbiota; segmented filamentous bacteria (SFB); T-HELPER; 17; INTESTINAL TH17 CELLS; REGULATORY T; MICROBIOME; INFECTION; RESPONSES; BACTERIA; ANXIETY;

D O I：

10.3389/fpsyt.2024.1509191

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Depression is a serious cognitive disorder that results in significant and pervasive deficits in social behavior. These deficits can be traced back to the intricate interplay between social, psychological, and biological factors. Inflammatory depression, a treatment-resistant or non-responsive subtype of depression, may be related to the interaction between the gut microbiota and interleukin-17-producing CD4+ T cells (Th17 cells). The heterogeneity, plasticity, and effector role of Th17 cells in depression may be influenced by microbiota factors. Commensals-elicited homeostatic Th17 cells preserve the morphological and functional integrity of the intestinal barrier. In addition to pathogen-elicited inflammatory Th17 cells, commensal-elicited homeostatic Th17 cells can become conditionally pathogenic and contribute to the development of inflammatory depression. This review delves into the possible involvement of Th17 cells in inflammatory depression and examines the interplay between gut microbiota and either homeostatic or inflammatory Th17 cells.

引用

页数：9

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