Alkoxy Substituted Brominated closo-Dodecaborates with Functionalized Aliphatic Spacers

被引：0

作者：

Yamamoto, Satoshi ^{[1
]}

Nakamura, Hibiki ^{[1
]}

Kawamura, Yumiko K. ^{[2
]}

Kitazawa, Taro ^{[2
]}

Kimura, Mutsumi ^{[1
,3
]}

Kitazawa, Yu ^{[3
]}

机构：

[1] Shinshu Univ, Fac Text Sci & Technol, Dept Chem & Mat, Ueda 3868567, Japan

[2] Aarhus Univ, Dept Mol Biol & Genet, Univ Byen 81, DK-8000 Aarhus, Denmark

[3] Shinshu Univ, Res Initiat Supramat RISM, Ueda 3868567, Japan

来源：

CHEMISTRY-SWITZERLAND | 2024年 / 6卷 / 06期

基金：

欧洲研究理事会;

关键词：

boron cluster; chaotropic; membrane transport; HYDROXYLATION; CHEMISTRY; CLUSTERS; ANION;

D O I：

10.3390/chemistry6060099

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The utilization of dodecaborate boron clusters, [B12X12]2- (X = Cl, Br, or I), as membrane carriers has been demonstrated recently, and their activity is known to be due to their superchaotropic nature. In this work, the mono-alkylation of [B12Br11OH]2- to functionalize it with an aliphatic spacer was developed with a view to expanding the known chemical space of membrane carriers based on [B12Br12]2-. A new and improved facile route for the preparation of [B12Br11OH]2-, which is an important precursor to other [B12Br11OR]2- species, is reported. Various alkoxylated [B12Br11O(CH2)5Z]2- (Z = OH, N(CO)2C6H4, CN and N3) derivatives were prepared via a divergent synthesis based on [B12Br11O(CH2)5Br]2-. One of the newly synthesized compounds was utilized as a membrane carrier, and its impact on cell viability was examined.

引用

页码：1635 / 1644

页数：10