Lymphocyte-to-Monocyte Ratio as a Prognostic Biomarker for Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

被引：0
作者：
Gu, Hanshuo [1 ]
Lu, Yian [1 ]
Luo, Jiaxin [1 ]
Yuan, Zhaoshun [1 ,2 ]
机构：
[1] Cent South Univ, Dept Cardiovasc Surg, Te Xiangya Hosp 2, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Dept Cardiovasc Surg, Xiangya Hosp 2, Guilin Hosp, Guilin 541199, Guangxi, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2025年 / 2025卷 / 01期
关键词：
acute myocardial infarction; biomarker; lymphocyte-to-monocyte ratio; meta-analysis; prognosis; CORONARY-ARTERY-DISEASE; BLOOD-CELL SUBTYPES; REFLOW PHENOMENON; NEUTROPHIL; MORTALITY; ASSOCIATION; SEVERITY; INJURY; UNDERWENT; DEATH;
D O I：
10.1155/ijcp/5560827
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The prognostic value of lymphocyte-to-monocyte ratio (LMR) for acute myocardial infarction (AMI) has been underscored by multiple studies. Therefore, we initiated this meta-analysis to examine the correlation between LMR and prognostic outcomes in patients with AMI. Methods: A comprehensive literature search was conducted across multiple databases, including Embase, PubMed, Web of Science, and the Cochrane Library, covering the period from the inception of the databases to October 24, 2024, focusing on studies comparing mortality and/or incidence of major adverse cardiovascular events (MACEs) by the pooled odds ratios (ORs) and respective 95% confidence intervals (CIs) between different LMR levels in AMI patients. Results: Our meta-analysis encompasses 11 studies and involves a total of 7719 patients. The results indicate that individuals in the lower LMR group exhibit notably elevated mortality rates (OR = 2.43, 95% CI: 1.46-4.04, and p = 0.0006) and increased incidence of MACE (OR = 1.57, 95% CI: 1.27-1.95, and p = 0.0001) compared with those with high LMR. Subgroup analysis further reveals that lower LMR correlated with higher mortality and MACE in the context of confounding factors such as the sample size and cutoff value. Conclusion: Our meta-analysis confirms the prognostic value of LMR in AMI patients. Lower LMR levels correlate with elevated mortality and increased incidence of MACE. This implies the clinical potential of LMR as an effective prognostic biomarker aiding in better risk assessment, personalized treatment strategies, and improved clinical outcomes.
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页数：12
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