Goat milk-based infant formula regulates intestinal barrier function and promotes the production of short-chain fatty acids

被引：0

作者：

Chen, Qingxue ^{[1
]}

Cao, Ting ^{[1
]}

Tang, Hongwei ^{[1
]}

Zhou, Linyi ^{[2
,3
,4
]}

Zheng, Yuxuan ^{[1
]}

Cheng, Jinju ^{[1
]}

Li, Bailiang ^{[1
]}

Wang, Song ^{[1
]}

机构：

[1] Northeast Agr Univ, Coll Food Sci, Harbin 150030, Peoples R China

[2] Beijing Technol & Business Univ, Coll Food & Hlth, Beijing 100048, Peoples R China

[3] Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430000, Peoples R China

[4] Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430000, Peoples R China

来源：

FOOD SCIENCE AND HUMAN WELLNESS | 2024年 / 13卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Goat milk-based infant formula; Immune function; Short-chain fatty acid; Human microbiota associated mice; SECRETORY IGA; MICROBIOME;

D O I：

10.26599/FSHW.2023.9250002

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Infant formula (IF) based on cow milk and goat milk is a substitute food for infants who are underfed with human milk. In our previous study, we reported the composition and physicochemical stability of IF based on milk from cows and goats and a combination of both milks. Here, we investigated the effects of these 3 IFs on intestinal immunity and short-chain fatty acid production (SCFAs) using human microbiota-associated (HMA) mice and selected human milk as a positive control. The results showed that goat milk-based IF is associated with a functional immune advantage, due to the rise in the levels of immune-related cytokines interleukin (IL)-2 and IL-10, decreased levels of intestinal permeability markers D-lactic acid and endotoxin, and increased mRNA levels of intestinal tight junction proteins occludin and claudin. In addition, the intestine of mice fed with goat milk-based IF contained 12.06 mu mol/g acetate, 2.42 mu mol/g propionate, and 1.72 mu mol/g butyrate, which reached 69%, 79%, and 60% of the levels in human milk, respectively. Our results indicate that goat milk-based IF improves intestinal immune function and promotes the production of intestinal SCFAs. (c) 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：3150 / 3158

页数：9

共 47 条

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