Orthostatic test shows higher systolic blood pressure and sympathetic response in uncomplicated type 1 diabetes patients with normal VO2max vs. healthy controls

被引：0

作者：

Sorola, Samu ^{[1
,2
]}

Hyryla, Vesa ^{[2
]}

Eronen, Timo ^{[1
]}

Kupari, Saana ^{[2
]}

Venojarvi, Mika ^{[1
]}

Tikkanen, Heikki ^{[1
]}

Tarvainen, Mika ^{[2
,3
]}

Lindholm, Harri ^{[1
]}

机构：

[1] Univ Eastern Finland, Inst Biomed Sports & Exercise Med, Kuopio, Finland

[2] Univ Eastern Finland, Dept Tech Phys, Kuopio, Finland

[3] Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland

来源：

CLINICAL AUTONOMIC RESEARCH | 2024年

关键词：

Type; 1; diabetes; Heart rate variability; Deep breathing test; Orthostatic test; Cardiorespiratory fitness; HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; AUTONOMIC NEUROPATHY; ARTERIAL STIFFNESS; R-R; POWER; MELLITUS; HUMANS;

D O I：

10.1007/s10286-024-01094-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

PurposeCardiovascular autonomic neuropathy remains underdiagnosed in type 1 diabetes mellitus, posing a risk for severe complications, particularly in patients with lowered VO2max, compared to controls. This study aimed to determine whether heart rate variability during cardiovascular autonomic reflex tests reveals early signs of cardiovascular autonomic neuropathy in patients with uncomplicated type 1 diabetes mellitus and normal cardiovascular fitness, compared to healthy controls.MethodsA type 1 diabetes mellitus group (n = 14) with no other diagnosed diseases (diabetes duration 15 +/- 7 years) and a control group (n = 31) underwent deep breathing test, passive orthostatic test, and cardiopulmonary exercise test. Participants were assessed for heart rate variability, heart rate, blood pressure, and VO2max (mL/min/kg).ResultsParticipant characteristics, including VO2max (mL/min/kg), showed no significant differences. The type 1 diabetes mellitus group had higher systolic blood pressure during the supine phase of the orthostatic test than healthy controls (131.6 +/- 14.7 mmHg vs. 122.4 +/- 10.8 mmHg, p = 0.022). After 5 mins in the upright position, systolic blood pressure (132.2 +/- 20.6 mmHg vs. 118.7 +/- 11.7 mmHg, p = 0.036), heart rate (85 (76; 89) bpm vs. 75 (72; 83) bpm, p = 0.013), and the root mean square of successive RR interval differences (20.22 (11.22; 27.42) vs. 27.11 (19.90; 35.52), p = 0.033) were significantly different compared to controls.ConclusionPatients with uncomplicated type 1 diabetes mellitus, despite having normal cardiorespiratory fitness, exhibited higher systolic pressure and greater sympathetic activation in orthostatic tests, suggesting subclinically altered cardiovascular autonomic function.

引用

页数：11