Antioxidant, anti-inflammatory, antiulcerogenic, and haemolytic properties of hydroethanolic and aqueous extracts from Tabernaemontana crassa Benth. fruit

被引：0

作者：

Saadi, Fatima Zahra ^{[1
]}

Merghache, Djamila ^{[1
]}

Boucherit-Otmani, Zahia ^{[1
]}

Benariba, Kaddour ^{[2
]}

Rahmoun, Asmaa ^{[2
]}

Ghanemi, Fatima Zahra ^{[2
]}

Yelles, Nabila ^{[3
]}

Sekkal, Nesrine ^{[3
]}

Bellaoueur, Ibtissem ^{[4
]}

Hassani, Faycal ^{[5
]}

Rahmani, Youcef ^{[4
]}

机构：

[1] Tlemcen Univ, Fac Nat Sci & Life Sci Earth & Universe, Dept Biol, Lab Antibiot Antifungal Physicochem Synth & Biol A, Tilimsen, Algeria

[2] Tlemcen Univ, Dept Biol, Fac Nat Sci Life Earth & Universe Sci, Lab Nat Prod LAPRONA, Tilimsen, Algeria

[3] Tlemcen Univ Hosp, Dept Med, Anat Pathol Lab, Tilimsen, Algeria

[4] Sci & Tech Res Ctr Physicochem Anal CRAPC, Ouargla, Algeria

[5] Tlemcen Univ, Dept Ecol & Environm, Lab Ecol & Management Nat Ecosyst, SNV STU Fac, Tilimsen, Algeria

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Tabernaemontana crassa; antioxidant activity; anti-inflammatory activity; anti-ulcer activity; haemolytic ability; ALKALOIDS; ACID;

D O I：

10.1080/14786419.2024.2418452

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Anti-inflammatory, antioxidant, antiulcer, and cytotoxic properties of hydroethanolic and aqueous extracts from the fruits of Tabernaemontana crassa were investigated. Four phenolic compounds, including three phenolic acids (gallic, caffeic, and chlorogenic acids) and one flavonol (rutin), were detected by HPLC-PDA. The hydroethanol extract (HE) exhibited high antioxidant activity and inhibition of haemolysis against red blood cells. Administration of HE (200 mg kg-1) significantly decreased the paw edoema induced by carrageenan compared to diclofenac sodium (20 mg kg-1). At the same dose, HE exhibited appreciable gastric cytoprotective capacity compared to Lanzoprazole (20 mg kg-1). These results were further supported by the histological analysis. Crude fruit extracts demonstrated a low haemolytic effect against rat red blood cells. Our findings support the use of T. crassa fruit in pharmacological and therapeutic fields.

引用

页数：7

共 26 条

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