Association of N, N-diethyl-m-toluamide (DEET) with arthritis among adult participants

被引：0
作者：
Lv, Taihong [1 ]
Yu, Hanming [2 ]
Ji, Zishuo [3 ]
Chen, Yuru [1 ]
Zhao, Qi [1 ]
Ma, Li [1 ]
机构：
[1] Capital Med Univ, Beijing TianTan Hosp, Dept Gen Med, Beijing, Peoples R China
[2] China Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 4, Shenyang, Peoples R China
[3] Capital Med Univ, Beijing TianTan Hosp, Dept Neurol, Beijing, Peoples R China
来源：
PLOS ONE | 2024年 / 19卷 / 12期
关键词：
RHEUMATOID-ARTHRITIS; INSECT REPELLENTS; NATIONAL-HEALTH; OSTEOARTHRITIS; EFFICACY; EXPOSURE;
D O I：
10.1371/journal.pone.0313012
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background N, N-diethyl-m-toluamide (DEET), an active ingredient prevalent in insect repellents, has its effects on human health under ongoing debate and scrutiny. Objective This study aimed to investigate the association between exposure to DEET and arthritis outcomes within the broader adult demographic, leveraging data obtained from the National Health and Nutrition Examination Survey (NHANES). Methods 3-diethyl-carbamoyl benzoic acid (DCBA) was used as a specific indicator of DEET exposure. Drawing on NHANES 2007-2016 data, our study incorporated 7065 adults to examine urinary DCBA impacts on arthritis risks using logistic regression and cubic spline analysis. Results Our study included a total of 7065 patients, of which 1860 (26.33%) had arthritis. After adjusting for all covariates, the multivariate logistic regression analysis showed that high DCBA levels (>7.37 ug/L) were associated with an increased likelihood of arthritis (OR: 1.236, 95% CI: 1.037-1.474, p = 0.018). Nevertheless, participants in the highest quartile of DCBA levels (Q4) were associated with a 33.9% decreased risk of rheumatoid arthritis (OR: 0.661; 95% CI: 0.501-0.872; p = 0.003). Conclusion It was observed that increased levels of DCBA are positively associated with the prevalence of arthritis in the adult population. Conversely, high concentrations of DCBA showed a reverse correlation with the prevalence of rheumatoid arthritis.
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页数：13
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共 38 条
  • [1] Ma L, Cranney A, Holroyd-Leduc JM, Acute monoarthritis: what is the cause of my patient’s painful swollen joint?, Cmaj, 180, 1, pp. 59-65, (2009)
  • [2] Murphy G, Nagase H, Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?, Nat Clin Pract Rheumatol, 4, 3, pp. 128-135, (2008)
  • [3] Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM, Genetic and environmental risk factors for rheumatoid arthritis, Best Pract Res Clin Rheumatol, 31, 1, pp. 3-18, (2017)
  • [4] Safiri S, Kolahi AA, Hoy D, Smith E, Bettampadi D, Mansournia MA, Et al., Global, regional and national burden of rheumatoid arthritis 1990–2017: a systematic analysis of the Global Burden of Disease study 2017, Ann Rheum Dis, 78, 11, pp. 1463-1471, (2019)
  • [5] Finckh A, Gilbert B, Hodkinson B, Bae SC, Thomas R, Deane KD, Et al., Global epidemiology of rheumatoid arthritis, Nat Rev Rheumatol, 18, 10, pp. 591-602, (2022)
  • [6] Smolen JS, Aletaha D, McInnes IB, Rheumatoid arthritis, Lancet, 388, 10055, pp. 2023-2038, (2016)
  • [7] Venetsanopoulou AI, Alamanos Y, Voulgari PV, Drosos AA, Epidemiology of rheumatoid arthritis: genetic and environmental influences, Expert Rev Clin Immunol, 18, 9, pp. 923-931, (2022)
  • [8] Choi IA, Lee JS, Song YW, Lee EY, Mortality, disability, and healthcare expenditure of patients with seropositive rheumatoid arthritis in Korea: A nationwide population-based study, PLoS One, 14, 1, (2019)
  • [9] Matcham F, Scott IC, Rayner L, Hotopf M, Kingsley GH, Norton S, Et al., The impact of rheumatoid arthritis on quality-of-life assessed using the SF-36: a systematic review and meta-analysis, Semin Arthritis Rheum, 44, 2, pp. 123-130, (2014)
  • [10] Buchel K, Bendin J, Gharbi A, Rahlenbeck S, Dautel H, Repellent efficacy of DEET, Icaridin, and EBAAP against Ixodes ricinus and Ixodes scapularis nymphs (Acari, Ixodidae), Ticks Tick Borne Dis, 6, 4, pp. 494-498, (2015)
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