Effect of vagal nerve stimulation on patients with bilateral temporal lobe epilepsy

被引：1

作者：

Alshahrani, Ashwaq ^{[1
]}

Burneo, Jorge G. ^{[1
,2
,3
]}

Steven, David A. ^{[1
,3
]}

Jones, Michelle-Lee ^{[1
]}

MacDougall, Keith W. ^{[1
]}

Lau, Jonathan C. ^{[1
]}

Debicki, Derek B. ^{[1
]}

Gofton, Tenielle ^{[1
]}

Diosy, David C. ^{[1
]}

McLachlan, Richard S. ^{[1
]}

Marti, Ana Suller ^{[1
,4
,5
]}

机构：

[1] Western Univ, Schulich Sch Med & Dent, Dept Clin Neurol Sci, Epilepsy Program, London, ON, Canada

[2] Western Univ, Schulich Sch Med & Dent, Neuroepidemiol Unit, London, ON, Canada

[3] Western Univ, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada

[4] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada

[5] Western Univ, Schulich Sch Med & Dent, Dept Paediat, London, ON, Canada

来源：

EPILEPSY & BEHAVIOR | 2024年 / 161卷

关键词：

Epilepsy; Bitemporal epilepsy; Focal seizures; Seizures; Temporal epilepsy; Vagus nerve stimulation; SEMIOLOGY;

D O I：

10.1016/j.yebeh.2024.110138

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Objective: To investigate the effects of vagus nerve stimulation (VNS) on the seizure frequency in patients with drug-resistant epilepsy (DRE) and bilateral temporal lobe epilepsy (bi-TLE). Additionally, we aimed to determine the safety of VNS and its side effects. Methods: Our retrospective study included 17 patients with bi-TLE who underwent VNS-device implantation at our center from 1997 to 2019. The main outcome was a reduction in seizure frequency. Bitemporal cases were confirmed using scalp electroencephalography (EEG) or invasive electroencephalography (iEEG). Results: The median age at seizure onset was 18 years. Bi-TLE was confirmed by scalp EEG in 47 % and by iEEG in 53 % of the patients. The median follow-up period was 36 months. The median seizure frequency per month before and after VNS was 9.5 (IQR = 4.3-35.3) and 2 (IQR = 0.8-4.2), respectively. Compared to baseline, 70.5 % of the patients achieved >= 50 % reduction in seizure frequency, whereas 35.3 % experienced either no or minimal reduction in seizure frequency. The response rate (>50 % reduction in seizure frequency) was 87.5 % in patients who underwent scalp EEG and 55.5 % in those who underwent iEEG. For VNS treatment, the median follow-up was at 36 months (IQR = 17-46.5). Adverse effects were observed in 59 % of the patients, including cough and hoarseness. Discussion: Therapeutic choices are limited in cases of drug-resistant bi-TLE. Our study on VNS-device implantation in bi-TLE suggests a positive outcome.

引用

页数：4

共 12 条

[1] Vagus nerve stimulation for the treatment of bilateral independent temporal lobe epilepsy [J].