Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer's Disease

被引：0

作者：

Romero-ElKhayat, Leila ^{[1
]}

Dakterzada, Farida ^{[1
]}

Huerto, Raquel ^{[1
]}

Carnes-Vendrell, Anna ^{[1
]}

Minguez, Olga ^{[2
]}

Sabate, Montserrat Pujol ^{[2
]}

Targa, Adriano ^{[3
,4
]}

Barbe, Ferran ^{[3
,4
]}

Milanesi, Elena ^{[5
,6
]}

Dobre, Maria ^{[5
]}

Manda, Gina ^{[5
]}

Cuadrado, Antonio ^{[5
,7
,8
,9
,10
]}

Pinol-Ripoll, Gerard ^{[1
,11
]}

机构：

[1] Univ Lleida, Cognit & Behav Study Grp, Unitat Trastorns Cognitius, IRBLleida, Lleida 25198, Spain

[2] Hosp Univ Santa Maria Lleida, Unitat Son, Lleida, Spain

[3] Hosp Univ Arnau de Vilanova & Santa Maria, Grp Translat Res Resp Med, IRBLleida, Lleida, Spain

[4] Ctr Biomed Res Resp Dis Network CIBERES, Madrid, Spain

[5] Victor Babes Natl Inst Pathol, Bucharest 050096, Romania

[6] Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania

[7] Inst Invest Biomed Alberto Sols UAM CSIC, Dept Endocrine Physiol & Nervous Syst, Madrid 28029, Spain

[8] Autonomous Univ Madrid, Fac Med, Dept Biochem, Madrid 28049, Spain

[9] Inst Invest Sanitaria La Paz Idipaz, Neurosci Sect, Madrid 28046, Spain

[10] ISCIII, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28031, Spain

[11] Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Fundacio Recerca Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2025年 / 18卷

关键词：

Alzheimer's disease; obstructive sleep apnea; oxidative stress; inflammation; gene expression; NF-kappa B signaling; FACTOR-KAPPA-B; COGNITIVE IMPAIRMENT; INTERMITTENT HYPOXIA; OXIDATIVE STRESS; ACTIVATION; ASSOCIATION; DEMENTIA; RISK;

D O I：

10.2147/JIR.S475776

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: Obstructive sleep apnoea (OSA) is the sleep disorder most frequently found in patients with Alzheimer's disease (AD). The intermittent hypoxia (IH) caused by OSA may participate in AD pathogenesis through increase in oxidative damage and inflammation. We aimed to identify inflammatory and redox genes differentially expressed in the blood from AD patients with severe OSA compared with those with nonsevere OSA. Methods: We included 40 AD patients diagnosed based on clinical manifestations and AD biomarker levels in cerebrospinal fluid (CSF). Severe or nonsevere OSA (apnoea-hypopnea index >= 30/h and < 30/h, respectively) was diagnosed through overnight polysomnography (PSG). The expression levels of 136 inflammation-related and 84 redox-related genes were evaluated by whole blood targeted transcriptomics. Results: Three inflammatory and six redox genes were upregulated in the blood of AD patients with severe OSA. Three of them correlated with PSG parameters. A pathway enrichment analysis showed a strong enrichment of the serotonergic synapse pathway in severe OSA AD Patients. Discussion: Our results show an upregulation of nine genes involved in NF-kappa B-mediated inflammation and redox metabolism in the blood of patients with mild AD with severe OSA. Therefore, severe OSA may worsen the inflammation and oxidative damage that are already altered in patients with AD.

引用

页码：1609 / 1621

页数：13

共 58 条

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