Impact of myocardial injury on cardiovascular complications in hospitalized patients with COVID-19: insights from Latin America

被引：1

作者：

Cardenas-Marin, Paula Andrea ^{[1
,2
,3
]}

Cordoba-Melo, Brayan Daniel ^{[1
,2
,3
]}

Carrillo-Gomez, Diana Cristina ^{[2
]}

Leon-Giraldo, Hoover ^{[1
,3
]}

Mendoza, Ivan ^{[4
]}

Florez, Noel ^{[2
]}

Gomez, Ricardo Enrique Larrea ^{[5
]}

Mercedes, Jessica Mirella ^{[6
]}

Herrera, Cesar J. ^{[7
]}

Lugo-Pena, Julian ^{[8
]}

Cardenas-Aldaz, Liliana Patricia ^{[9
]}

Rossel, Victor ^{[10
]}

Ramirez, Ricardo Ramirez ^{[11
]}

Fernandez, Hugo Fernando ^{[12
]}

Retana, Andres Ulate ^{[13
]}

Martinez, J. Daniel Sierra-Lara ^{[14
]}

Figueiredo, Estevao Lanna ^{[15
]}

Galindo, Wilbert German Yabar ^{[16
]}

Da Silva, Miguel Angel Quintana ^{[17
]}

Romero, Alexander ^{[18
]}

Silva, Paula ^{[19
]}

Alvarado, Armando ^{[20
]}

Valencia, Andrea ^{[1
]}

Gomez-Mesa, Juan Esteban ^{[1
,2
,3
]}

机构：

[1] Fdn Valle Lili, Ctr Invest Clin, Cali, Colombia

[2] Fdn Valle Lili, Dept Med Interna, Serv Cardiol, Cali, Colombia

[3] Univ Icesi, Fac Ciencias Salud, Cali, Colombia

[4] Univ Cent Venezuela, Inst Med Trop, Caracas, Venezuela

[5] Clin Davila, Dept Cardiol, Santiago, Chile

[6] Hosp Nacl Rosales, Dept Enfermeria, San Salvador, El Salvador

[7] CEDIMAT Cardiovasc Ctr, Ctr Diagnost & Med Avanzada & Conf Med & Telemed, Santo Domingo, Dominican Rep

[8] Clin Occidente, Dept Cardiol, Bogota, Colombia

[9] Hosp Eugenio Espejo, Dept Cardiol, Quito, Ecuador

[10] Univ Chile, Hosp Salvador, Fac Med, Secc Cardiol, Santiago, Chile

[11] Inst Nacl Torax, Dept Cardiol, Santiago, Chile

[12] Clin San Francisco, Dept Cardiol, Tulua, Colombia

[13] Hosp Mexico Pozos, Secc 12, Santa Ana 10107, Costa Rica

[14] Inst Nacl Cardiol Ignacio Chavez, Unidad Cuidados Crit Cardiovasc, Mexico City, Mexico

[15] Hosp Vera Cruz SA, Dept Cardiol, Belo Horizonte, MG, Brazil

[16] Hosp Nacl Guillermo Almenara Irigoyen, Dept Cardiol, Lima, Peru

[17] Inst Cardiovasc Sanat Migone, Unidad Coronaria, Asuncion, Paraguay

[18] Hosp Santo Tomas, Ciudad De Panama, Panama

[19] Favaloro Fdn Univ Hosp, Dept Cardiol, Buenos Aires, Argentina

[20] Hosp Especializado Villa Nueva, Villa Nueva 01064, Guatemala

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2025年 / 12卷

关键词：

myocardial injury; covid-19; cardiovascular complications; hospital mortality; troponin levels; INFARCTION; INFECTION; DISEASE;

D O I：

10.3389/fcvm.2025.1545142

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction Viral infection by SARS-CoV2 is a pandemic affecting over 600 million people worldwide. One of five hospitalized patients may present myocardial injury, strongly associated with disease severity and mortality.Methodology Retrospective cross-sectional study of hospitalized COVID-19 patients diagnosed between May 01, 2020, and June 30, 2021, from the database of the Registro Latinoamericano de Enfermedad Cardiovascular y COVID-19 (CARDIO COVID 19-20) with a troponin value recorded during hospitalization. A descriptive analysis of sociodemographic and clinical characteristics was performed. Bivariate analysis was conducted according to the presence or absence of myocardial injury. Survival analysis was made using Kaplan-Meier curves, by the presence of myocardial injury. A multivariate Poisson regression model was performed to determine factors associated with mortality. Statistical analyses were performed using the RStudio V.1.4.1717 package.Results A total of 2,134 patients were included, 64.2% were male, and 911 patients had myocardial injury. The median age of the total population was 61 years. Individuals with myocardial injury had a higher prevalence of hypertension, diabetes, and dyslipidemia. Survival probability was lower in this subgroup. Patients with myocardial injury had a 1.95 times higher risk of death. Age, male sex, chronic kidney disease, arrhythmias, decompensated heart failure, requirement of inotropic/vasopressor, and invasive mechanical ventilation were related to higher mortality risk in patients with myocardial injury.Conclusion Patients with COVID-19 and myocardial injury exhibit a broad spectrum of cardiac abnormalities. Myocardial injury is associated with a higher disease severity and risk of in-hospital mortality. This multicenter study uniquely represents data from 13 Latin American countries, offering regional insights into the impact of myocardial injury during the COVID-19 pandemic.

引用

页数：10

共 50 条

[21] Abortion and the COVID-19 pandemic: insights for Latin America [J].

Pilecco, Flavia Bulegon ;

McCallum, Cecilia Anne ;

Chagas de Almeida, Maria da Conceicao ;

Oliveira Alves, Flavia Jose ;

Rocha, Aline dos Santos ;

Ortelan, Naia ;

Gabrielli, Ligia ;

de Souza Menezes, Greice Maria .

CADERNOS DE SAUDE PUBLICA, 2021, 37 (06)

[22] Cardiovascular complications in COVID-19 [J].

Long, Brit ;

Brady, William J. ;

Koyfman, Alex ;

Gottlieb, Michael .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2020, 38 (07) :1504-1507

[23] Cardiovascular Complications in COVID-19 [J].

Valova, T. .

NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, 2022, 18 (02) :85-100

[24] The cardiovascular complications in COVID-19: Focus on acute cardiac injury [J].

Saeed, Sahrai ;

Rajani, Ronak .

PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2021, 37 (03) :908-912

[25] Types of myocardial injury and mid-term outcomes in patients with COVID-19 [J].

Kini, Annapoorna ;

Cao, Davide ;

Nardin, Matteo ;

Sartori, Samantha ;

Zhang, Zhongjie ;

Pivato, Carlo Andrea ;

Chiarito, Mauro ;

Nicolas, Johny ;

Vengrenyuk, Yuliya ;

Krishnamoorthy, Parasuram ;

Sharma, Samin K. ;

Dangas, George ;

Fuster, Valentin ;

Mehran, Roxana .

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES, 2021, 7 (05) :438-446

[26] Site-level variability in the processes of care and outcomes over time among patients with COVID-19 and myocardial injury: Insights from the American Heart Association's COVID-19 Cardiovascular Disease Registry [J].

Sammour, Yasser M. ;

Spertus, John A. ;

Kennedy, Kevin ;

Morrow, David A. ;

Daniels, Lori B. ;

Jones, Phil ;

Alger, Heather ;

Stevens, Laura ;

Shah, Alpesh ;

Goel, Sachin S. ;

Lemos, James A. de ;

Hayek, Salim S. ;

Sutton, Nadia R. ;

Kleiman, Neal S. .

AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE, 2023, 27

[27] Impact of COVID-19 pandemic on patients with rheumatic diseases in Latin America [J].

Fernandez-Avila, Daniel G. ;

Barahona-Correa, Julian ;

Romero-Alvernia, Diana ;

Kowalski, Sergio ;

Sapag, Ana ;

Cachafeiro-Vilar, Antonio ;

Melendez, Belia ;

Pastelin, Carlos ;

Palleiro, Daniel ;

Arrieta, Dina ;

Reyes, Gil ;

Pons-Estel, Guillermo J. ;

Then-Baez, Jossiell ;

Ugarte-Gil, Manuel F. ;

Cardiel, Mario H. ;

Colman, Nelly ;

Chavez, Nilmo ;

Burgos, Paula, I ;

Montufar, Ruben ;

Sandino, Sayonara ;

Fuentes-Silva, Yurilis J. ;

Soriano, Enrique R. .

RHEUMATOLOGY INTERNATIONAL, 2022, 42 (01) :41-49

[28] Impact of COVID-19 pandemic on patients with rheumatic diseases in Latin America [J].

Daniel G. Fernández-Ávila ;

Julián Barahona-Correa ;

Diana Romero-Alvernia ;

Sergio Kowalski ;

Ana Sapag ;

Antonio Cachafeiro-Vilar ;

Belia Meléndez ;

Carlos Pastelín ;

Daniel Palleiro ;

Dina Arrieta ;

Gil Reyes ;

Guillermo J. Pons-Estel ;

Jossiell Then-Báez ;

Manuel F. Ugarte-Gil ;

Mario H. Cardiel ;

Nelly Colman ;

Nilmo Chávez ;

Paula I. Burgos ;

Rubén Montufar ;

Sayonara Sandino ;

Yurilis J. Fuentes-Silva ;

Enrique R. Soriano .

Rheumatology International, 2022, 42 :41-49

[29] Cardiopulmonary Imaging Utilization and Findings among Hospitalized COVID-19 Patients in Latin America [J].

Spina, Salvador, V ;

Vieira, Marcelo L. Campos ;

Herrera, Cesar J. ;

Echeverri, Ana G. Munera ;

Rojo, Pamela ;

Arrioja Salazar, Alma S. ;

Vazquez Ortiz, Zuilma Y. ;

Baltodano Arellano, Roberto ;

Reyes, Graciela ;

Aceves Millan, Rocio ;

Calderon Gonzalez, Juan A. ;

Camarozano, Ana C. ;

Aviles, Edgar ;

Cabrera, Marco A. ;

Grande Ratti, Maria F. ;

Lowenstein, Jorge ;

Hernandez Vyhmeister, Rodrigo ;

Santana, Pamela Pina ;

Burgos, Jaime A. Ibarra ;

Rivera, Alejandra ;

Fernandez Campos, Beatriz A. ;

Cupe Chacalcaje, Kelly M. ;

De Santos, Mariela ;

Afonso, Tania R. ;

Miranda Aquino, Tomas ;

Acosta, Ana L. Lalyre ;

Dominguez, Beatriz ;

Campos, Federico ;

Alday Ramirez, Sergio M. ;

Beltran, Angela V. Cachicatari ;

Alvarez, Daniela ;

Roveri, Patricia de Oliveira ;

Ixcamparij, Carlos Rosales ;

Gonzalez, Ender Otoniel ;

Vargas, Pedro ;

Flores Flamand, Maximiliano ;

Lopez Martinez, Rosa L. ;

Meza, Luciana ;

Morhy, Samira Saady ;

Ovalle, Rudy ;

Martinez, Stalin ;

Perez Orpinel, Oscar A. ;

Potito, Mauricio ;

Arregui, Maria Veronica Espinoza ;

Baez, Jorge Marte ;

Orihuela Sandoval, Consuelo ;

Granillo Fernandez, Marcos ;

Loomba, Rohit ;

Flores, Saul ;

Hernandez, Jose M. .

GLOBAL HEART, 2022, 17 (01)

[30] Myocardial injury and related mortality in hospitalized patients with COVID-19 during the Omicron pandemic: new perspectives and insights [J].

He, Wu ;

Xu, Ke ;

Ni, Li ;

Wu, Junfang ;

Zhang, Yuxuan ;

Miao, Kun ;

Wang, Luyun ;

Wang, Dao Wen .

VIROLOGICA SINICA, 2023, 38 (06) :940-950

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