SIRT3, a New Hope in Liver Diseases from Pathogenic Mechanisms to Therapeutic Strategies

被引:1
|
作者
Tan, Sai-Ya [1 ]
Chen, Xiao-Xuan [1 ]
Zhang, Rui [1 ]
Liu, Pan [1 ]
Wang, Jian-Peng [1 ]
Wang, Ting [1 ,2 ]
Xiong, Zhang-E [3 ]
机构
[1] Wuhan Univ Sci & Technol, Inst Pharmaceut Proc, Acad Nutr & Hlth, Coll Med, Wuhan 430065, Peoples R China
[2] Asia Gen Hosp, Wuhan 430065, Peoples R China
[3] Wuhan Third Hosp, Dept Gastroenterol, Wuhan, Peoples R China
基金
中国国家自然科学基金;
关键词
SIRT3; liver disease; lipid metabolism; mitochondrial autophagy; oxidative stress; SIRT3-DEPENDENT DEACETYLATION; MITOCHONDRIAL DEACETYLASE; REPERFUSION INJURY; OXIDATIVE STRESS; ACTS; ACTIVATION; HOMOLOG; MICE; METABOLISM; SENESCENCE;
D O I
10.2174/0113892010340592241011052133
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The liver, the largest internal organ in the human body, regulates multiple reactions and processes, including detoxification, regeneration, and immune defense. Liver diseases have emerged as a significant global public health issue. Numerous studies have indicated that the mitochondrial deacetylase SIRT3 has played various roles in the pathogenesis and pathological progression of liver diseases.Objectives This review aims to explore the advances in the study of SIRT3 and liver disease and review possible mechanisms. Natural and chemical activators of SIRT3 are also discussed. The role of SIRT3 in the pathogenic mechanisms and therapeutic strategies of liver disease is summarized by reviewing Pubmed. SIRT3 alleviates liver diseases by regulating fatty acid metabolism, mitochondrial function, and immune-inflammatory response. Meanwhile, Withaferin A, lipoic acid, major royal jelly proteins, and berberine can activate SIRT3 or upregulate its expression, thereby alleviating liver damage. SIRT3 can effectively slow down the progression of liver disease and protect the liver from further damage. The use of SIRT3 as a pharmacological target for the treatment of liver disease is a potential therapeutic approach.
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页数:11
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