Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression

被引：0

作者：

da Graca, Catarina Gago ^{[1
]}

Sheikh, Amania A. ^{[1
]}

Newman, Dane M. ^{[2
,3
]}

Wen, Lifen ^{[1
]}

Li, Sining ^{[1
]}

Shen, Jian ^{[4
]}

Zhang, Yuqi ^{[4
]}

Gabriel, Sarah S. ^{[1
]}

Chisanga, David ^{[5
]}

Seow, Justine ^{[6
]}

Poch, Annika ^{[1
]}

Rausch, Lisa ^{[1
]}

Nguyen, Minh-Hanh T. ^{[1
]}

Singh, Jayendra ^{[5
]}

Su, Chun-Hsi ^{[1
]}

Cluse, Leonie A. ^{[2
,3
]}

Tsui, Carlson ^{[1
]}

Burn, Thomas N. ^{[1
]}

Park, Simone L. ^{[1
]}

Von Scheidt, Bianca ^{[1
]}

Mackay, Laura K. ^{[1
]}

Vasanthakumar, Ajithkumar ^{[5
]}

Bending, David ^{[7
]}

Shi, Wei ^{[5
,8
,9
]}

Cui, Weiguo ^{[4
]}

Schroeder, Jan ^{[6
]}

Johnstone, Ricky W. ^{[2
,3
]}

Kallies, Axel ^{[1
]}

Utzschneider, Daniel T. ^{[1
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Australia

[2] Peter MacCallum Canc Ctr, Canc Biol & Therapeut Program, Melbourne, Australia

[3] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Australia

[4] Northwestern Univ, Dept Pathol, Chicago, IL USA

[5] Olivia Newton John Canc Res Inst, Heidelberg, Australia

[6] Univ Melbourne, Peter Doherty Inst Infect & Immun, Computat Sci Initiat CSI, Melbourne, Australia

[7] Univ Birmingham, Coll Med & Hlth, Dept Immunol & Immunotherapy, Birmingham B15, England

[8] La Trobe Univ, Sch Canc Med, Heidelberg, Australia

[9] Monash Univ, Monash Biomed Discovery Inst, Dept Biochem & Mol Biol, Clayton, Australia

来源：

SCIENCE IMMUNOLOGY | 2025年 / 10卷 / 103期

基金：

英国医学研究理事会;

关键词：

LOOP-HELIX PROTEINS; CHRONIC INFECTION; VIRAL-INFECTION; EFFECTOR; SUBSET; DIFFERENTIATION; INFLAMMATION; LYMPHOCYTES; ORCHESTRATE; GENERATION;

D O I：

10.1126/sciimmunol.adn1945

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny. Thus, identifying T cells with enhanced stemness and understanding their developmental requirements are of broad clinical and therapeutic interest. Here, we demonstrate that during acute infection, the transcriptional regulator inhibitor of DNA binding 3 (ID3) identifies stem-like T cells that are uniquely adapted to generate precursors of exhausted T (Tpex) cells in response to chronic infection or cancer. Expression of ID3 itself enables Tpex cells to sustain T cell responses in chronic infection or cancer, whereas loss of ID3 results in impaired maintenance of CD8 T cell immunity. Furthermore, we demonstrate that interleukin-1 (IL-1) family members, including IL-36 beta and IL-18, promote the generation of ID3+ T cells that mediate superior tumor control. Overall, we identify ID3 as a common denominator of stem-like T cells in both acute and chronic infections that is specifically required to sustain T cell responses to chronic stimulation.

引用

页数：17

共 21 条

[21] Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model
Corgnac, Stephanie
Damei, Isabelle
Gros, Gwendoline
Caidi, Aziza
Terry, Stephane
Chouaib, Salem
Deloger, Marc
Mami-Chouaib, Fathia
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (04)

← 1 2 3 →