Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism

被引：6

作者：

Mosalmanzadeh, Negin ^{[1
]}

Pence, Brandt D. ^{[2
,3
]}

机构：

[1] Univ Memphis, Coll Hlth Sci, Memphis, TN 38111 USA

[2] Univ Memphis, Coll Hlth Sci, Memphis, TN 38111 USA

[3] Univ Memphis, Ctr Nutraceut & Dietary Supplement Res, Memphis, TN 38111 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 21期

关键词：

OxLDL; immunology; metabolism; inflammation; senescence; atherosclerosis; aging; MITOCHONDRIAL PERMEABILITY TRANSITION; T-CELL-ACTIVATION; DENDRITIC CELLS; DNA-DAMAGE; MACROPHAGE IMMUNOMETABOLISM; OXIDATIVE MODIFICATION; LDL; CHOLESTEROL; INFLAMMATION; SENESCENCE;

D O I：

10.3390/ijms252111386

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modified cholesterols such as oxidized low-density lipoprotein (OxLDL) contribute to atherosclerosis and other disorders through the promotion of foam cell formation and inflammation. In recent years, it has become evident that immune cell responses to inflammatory molecules such as OxLDLs depend on cellular metabolic functions. This review examines the known effects of OxLDL on immunometabolism and immune cell responses in atherosclerosis and several other diseases. We additionally provide context on the relationship between OxLDL and aging/senescence and identify gaps in the literature and our current understanding in these areas.

引用

页数：23

共 203 条

[1] TNFα induces matrix metalloproteinase-9 expression in monocytic cells through ACSL1/JNK/ERK/NF-kB signaling pathways [J].

Al-Roub, Areej ;

Akhter, Nadeem ;

Al-Rashed, Fatema ;

Wilson, Ajit ;

Alzaid, Fawaz ;

Al-Mulla, Fahd ;

Sindhu, Sardar ;

Ahmad, Rasheed .

SCIENTIFIC REPORTS, 2023, 13 (01)

[2] Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts [J].

Alcorta, DA ;

Xiong, Y ;

Phelps, D ;

Hannon, G ;

Beach, D ;

Barrett, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13742-13747

[3] Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach [J].

Aliyu, Mansur ;

Zohora, Fatema Tuz ;

Anka, Abubakar Umar ;

Ali, Kashif ;

Maleknia, Shayan ;

Saffarioun, Mohammad ;

Azizi, Gholamreza .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 111

[4] Mechanisms of fibrous cap formation in atherosclerosis [J].

Alonso-Herranz, Laura ;

Albarran-Juarez, Julian ;

Bentzon, Jacob Fog .

FRONTIERS IN CARDIOVASCULAR MEDICINE, 2023, 10

[5] DNA damage, vascular senescence and atherosclerosis [J].

Andreassi, Maria Grazia .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2008, 86 (09) :1033-1043

[6] Oxidized LDL promotes peroxide-mediated mitochondrial dysfunction and cell death in human macrophages - A caspase-3-independent pathway [J].

Asmis, R ;

Begley, JG .

CIRCULATION RESEARCH, 2003, 92 (01) :E20-E29

[7] MODIFIED FORMS OF LOW-DENSITY-LIPOPROTEIN AND ATHEROSCLEROSIS [J].

AVIRAM, M .

ATHEROSCLEROSIS, 1993, 98 (01) :1-9

[8] New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages [J].

Batista-Gonzalez, Ana ;

Vidal, Roberto ;

Criollo, Alfredo ;

Carreno, Leandro J. .

FRONTIERS IN IMMUNOLOGY, 2020, 10

[9] The Role of Oxidative Stress in Atherosclerosis [J].

Batty, Matthew ;

Bennett, Martin R. ;

Yu, Emma .

CELLS, 2022, 11 (23)

[10] Crosstalk between dendritic cells and T lymphocytes during atherogenesis: Focus on antigen presentation and break of tolerance [J].

Bellini, Rossella ;

Bonacina, Fabrizia ;

Norata, Giuseppe Danilo .

FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9

← 1 2 3 4 5 6 7 8 9 10 →