Calcium catalysed Strecker-type reactions towards α-aminonitriles

被引：1

作者：

Basson, Ashley J. ^{[1
]}

Cameron, Michael P. ^{[2
]}

Mclaughlin, Mark G. ^{[1
,2
]}

机构：

[1] Univ Lancaster, Dept Chem, Bailrigg LA1 4YQ, England

[2] Queens Univ Belfast, Sch Chem & Chem Engn, Belfast, North Ireland

来源：

CHEMICAL COMMUNICATIONS | 2025年 / 61卷 / 31期

基金：

英国工程与自然科学研究理事会;

关键词：

DIRECT CYANATION; HYDROLYSIS; NITRILES; ALCOHOLS;

D O I：

10.1039/d5cc00539f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report an operationally simple calcium catalysed Strecker type reaction for the synthesis of alpha-aminonitriles from readily available N,O-acetals. The reaction is tolerant to a wide range of useful functional groups, including heterocycles, and provides the product in good to excellent yields. Additionally, the reaction does not require the need for anhydrous or air-free conditions, making it a suitable candidate for high throughput experimentation.

引用

页码：5739 / 5741

页数：3