Toxicological investigation of 25 aconitine-induced deaths from 2005 to 2023

被引：0

作者：

Wang, Xinying ^{[1
,2
]}

Wang, Xin ^{[2
]}

Liu, Wei ^{[2
]}

Chen, Hang ^{[2
]}

Zhang, Zhen ^{[1
,2
]}

Zhao, Yunli ^{[1
]}

Xiang, Ping ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, Shenyang, Peoples R China

[2] Acad Forens Sci, Shanghai Forens Serv Platform, Shanghai Key Lab Forens Med, Key Lab Forens Sci,Minist Justice, Shanghai, Peoples R China

来源：

LEGAL MEDICINE | 2025年 / 72卷

关键词：

Forensic toxicology; Aconitine; Aconitum alkaloids; Herbal Poisoning; Postmortem; ALKALOIDS;

D O I：

10.1016/j.legalmed.2024.102564

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Aconitum herbs contain several highly toxic diester-diterpenoid alkaloids, including aconitine, mesaconitine, and hypaconitine. However, finding the cause of death is rather difficult for forensic pathologists during forensic autopsy of aconitine-induced death. Therefore, the ability to determine Aconitum alkaloids is important in these cases. The aim of this study was to review the data for alkaloids in postmortem specimens from 25 aconitine-induced deaths received by the Academy of Forensic Science from 2005 to 2023. Aconitum alkaloids were analyzed using an LC-MS/MS method, which was validated for blood, urine, and liver tissue. Briefly, 0.5 mL (g) of biological sample was subjected to liquid-liquid extraction with diethyl ether at pH 9.2. In 25 aconitineinduced deaths, the blood levels of aconitine, mesaconitine, and hypaconitine were 2.9-470 ng/mL (n = 22),

引用

页数：9

共 22 条

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