Synthesis of (1,10-Phenanthroline-κ2N,N′)(β2-Methyl- and β2-PhenylAlaninate-κ2N,O)Copper(II) Nitrate Complexes and Their Antiproliferative Activity on MCF-7 and A549 Cancer Cell Lines

被引：0

作者：

Chavelas-Hernandez, Leticia ^{[1
]}

Hernandez-Vazquez, Luis G. ^{[1
]}

Valdez-Camacho, Jonathan R. ^{[1
,2
]}

Espinoza-Guillen, Adrian ^{[3
]}

Tavira-Montalvan, Carlos A. ^{[4
]}

Meneses-Acosta, Angelica ^{[4
]}

Juaristi, Eusebio ^{[5
,6
]}

Ruiz-Azuara, Lena ^{[3
]}

Escalante, Jaime ^{[1
]}

机构：

[1] Univ Autonoma Estado Morelos, Ctr Invest Quim, IICBA, Ave Univ 1001, Cuernavaca 62209, Mexico

[2] Univ Autonoma Metropolitana Iztapalapa, Dept Quim, San Rafael Atlixco 186, Ciudad De Mexico 09340, Mexico

[3] Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Ave Univ 3000, Ciudad De Mexico 04510, Mexico

[4] Univ Autonoma Estado Morelos, Fac Farm, Ave Univ 1001, Cuernavaca 62209, Mexico

[5] Ctr Invest & Estudios Avanzados, Dept Quim, Ave IPN 2508, Ciudad De Mexico 07360, Mexico

[6] El Colegio Nacl, Ctr Hist, Calle Luis Gonzalez Obregon 23, Ciudad De Mexico 06020, Mexico

来源：

MOLECULES | 2025年 / 30卷 / 03期

关键词：

beta(2)-aminoacidates; Casiope & iacute; nas (R); copper; cytotoxic activity; CU(II) COMPLEXES; IN-VITRO; DNA; APOPTOSIS; EPR; VISUALIZATION; VALIDATION; BREAST; ACIDS;

D O I：

10.3390/molecules30030634

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, metallodrugs have been playing an important role, showing to be more efficient in the treatment of several diseases, such as cancer. Indeed, it is important to synthesize novel molecules to be used as more effective agents against cancer. In the present paper, the synthesis of two new molecules belonging to Casiope & iacute;nas (R) is reported. These compounds present a beta 2-aminoacidate derivative as the secondary ligand. The novel metal complexes were characterized by high-resolution mass spectrometry, FT-IR, UV-Vis, EPR, effective magnetic moment and cyclic voltammetry measurements, and single crystal X-ray diffraction analysis. Furthermore, these compounds were evaluated in vitro against the cancer lines MCF-7 (breast cancer) and A549 (lung cancer).

引用

页数：25

共 46 条

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