Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism: a cohort study

被引：0

作者：

Araujo-Castro, Marta ^{[1
,2
]}

Fano, Miguel Paja ^{[3
,4
]}

Gonzalez-Boillos, Marga ^{[5
]}

Pascual-Corrales, Eider ^{[1
,2
]}

Ramirez, Paola Parra ^{[6
]}

Rojas-Marcos, Patricia Martin ^{[6
]}

Garcia-Cano, Ana ^{[7
]}

Ruiz-Sanchez, Jorge Gabriel ^{[8
]}

Vicente, Almudena ^{[9
]}

Gomez-Hoyos, Emilia ^{[10
]}

Casteras, Ana ^{[11
]}

Puig-Perez, Albert ^{[11
]}

Sanz, Inigo Garcia ^{[12
]}

Recasens, Monica ^{[13
]}

San Millan, Rebeca Barahona ^{[13
]}

Cesar, Maria Jose Picon ^{[14
,15
]}

Guardiola, Patricia Diaz ^{[16
]}

Perdomo, Carolina ^{[17
]}

Manjon-Miguelez, Laura ^{[18
,19
]}

Roman, Angel Rebollo ^{[20
]}

Lazaro, Cristina Robles ^{[21
]}

Recio, Jose Maria ^{[21
]}

Morales-Ruiz, Manuel ^{[22
]}

Calatayud, Maria ^{[23
]}

Lopez, Noemi Jimenez ^{[23
]}

Meneses, Diego ^{[8
]}

Nunez, Miguel Sampedro ^{[24
]}

Ribas, Elena Mena ^{[25
]}

Sanchez, Alicia Sanmartin ^{[25
]}

Diaz, Cesar Gonzalvo ^{[26
]}

Lamas, Cristina ^{[26
]}

Tous, Maria del Castillo ^{[27
]}

Serrano, Joaquin ^{[28
]}

Michalopoulou, Theodora ^{[29
]}

Rodrigo, Susana Tenes ^{[30
]}

Chamorro, Ricardo Roa ^{[31
]}

Aguila, Fernando Jaen ^{[31
]}

Mateo, Eva Maria Moya ^{[32
]}

Gutierrez-Medina, Sonsoles ^{[33
]}

Hanzu, Felicia Alexandra ^{[34
]}

机构：

[1] Hosp Univ Ramon & Cajal, Endocrinol & Nutr Dept, Colmenar Viejo St Km 9, Madrid 28034, Spain

[2] Inst Invest Biomed Ramon & Cajal IRYCIS, Madrid 28034, Spain

[3] Hosp Univ Basurto, Endocrinol & Nutr Dept, OSI Bilbao Basurto, Bilbao 48013, Spain

[4] Univ Basque Country UPV EHU, Bilbao 48013, Spain

[5] Hosp Univ Castellon, Endocrinol & Nutr Dept, Castellon de La Plana 12004, Spain

[6] Hosp Univ La Paz, Endocrinol & Nutr Dept, Madrid 28046, Spain

[7] Hosp Univ Ramon & Cajal, Biochem Dept, Madrid 28034, Spain

[8] Hosp Univ Fdn Jimenez Diaz, Endocrinol & Nutr Dept, Madrid 28040, Spain

[9] Hosp Univ Toledo, Endocrinol & Nutr Dept, Toledo 45007, Spain

[10] Hosp Univ Valladolid, Endocrinol & Nutr Dept, Valladolid 47003, Spain

[11] Hosp Valle De Hebron, Endocrinol & Nutr Dept, Barcelona 08035, Spain

[12] Hosp Univ La Princesa, Gen & Digest Surg Dept, Madrid 28006, Spain

[13] Hosp De Girona Doctor Josep Trueta, Endocrinol & Nutr Dept, Girona 17007, Spain

[14] Hosp Univ Virgen de la Victoria Malaga, Endocrinol & Nutr Dept, IBIMA, Malaga 29010, Spain

[15] CIBEROBN, Madrid 29010, Spain

[16] Hosp Univ Infanta Sofia, Endocrinol & Nutr Dept, Madrid 28702, Spain

[17] Clin Univ Navarra, Endocrinol & Nutr Dept, Pamplona 28027, Spain

[18] Hosp Univ Cent Asturias, Endocrinol & Nutr Dept, Oviedo 33011, Spain

[19] Inst Invest Sanitaria Principado Asturias ISPA, Asturias 33011, Spain

[20] Hosp Reina Sofia, Endocrinol & Nutr Dept, Cordoba 14004, Spain

[21] Hosp Clin Univ Salamanca, Endocrinol & Nutr Dept, Salamanca 37007, Spain

[22] CIBERehd, IDIBAPS, Hosp Clin, Biochem & Mol Genet Dept CDB, Barcelona 08036, Spain

[23] Hosp Doce Octubre, Endocrinol & Nutr Dept, Madrid 28041, Spain

[24] Hosp Univ La Princesa, Endocrinol & Nutr Dept, Madrid 28006, Spain

[25] Hosp Univ Son Espases, Endocrinol & Nutr Dept, Illes Balears 07120, Spain

[26] CHU Albacete, Endocrinol & Nutr Dept, Albacete 02008, Spain

[27] Hosp Univ Virgen Macarena, Endocrinol & Nutr Dept, Seville 41009, Spain

[28] Hosp Gen Univ Alicante, Endocrinol & Nutr Dept, Alicante 03010, Spain

[29] Hosp Joan 23, Endocrinol & Nutr Dept, Tarragona 03550, Spain

[30] Hosp La Fe, Endocrinol & Nutr Dept, Valencia 46026, Spain

[31] Hosp Univ Virgen de las Nieves, Internal Med Dept, Granada 18014, Spain

[32] Hosp Univ Infanta Leonor, Internal Med, Madrid 28031, Spain

[33] Clin Univ Navarra, Endocrinol & Nutr Dept, Madrid 28027, Spain

[34] Univ Barcelona, Hosp Clin, Endocrinol & Nutr Dept, IDIPAS, Barcelona 08036, Spain

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2024年 / 191卷 / 06期

关键词：

primary aldosteronism; smoking; cigarettes; adrenalectomy; hypertension; ADRENAL INCIDENTALOMAS; BLOOD-PRESSURE; PREVALENCE; HYPERTENSION; CORTISOL; SMOKERS; GROWTH; DAMAGE;

D O I：

10.1093/ejendo/lvae143

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim To evaluate the influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism (PA).Methods Multicentre retrospective study of patients with PA evaluated in 36 Spanish tertiary hospitals with available information on smoking habits [smokers and non-smokers (never smokers and ex-smokers)].Results A total of 881 patients were included, of whom 180 (20.4%) were classified as smokers and 701 as non-smokers. At diagnosis, smokers and non-smokers did not differ in blood pressure or serum potassium levels between. However, smokers had a higher prevalence of left ventricular hypertrophy (LVH) than non-smokers [odds ratio (OR) 2.0, 95% confidence interval (CI) 1.23-3.25], and smokers were more likely to have severe LVH than non-smokers (12.5% vs 6.6%, P = .164). A larger mean tumour size of the adrenal nodule/s was observed in the smoking group (18.6 +/- 9.66 vs 15.8 +/- 8.66 mm, P = .002). In addition, the odds of mild autonomous cortisol secretion (MACS) was greater in smokers than in non-smokers (OR 2.1, 95% CI 1.14-4.06), but these differences disappeared when adjusted for the size of the adrenal nodule/s (adjusted OR 1.6, 95% CI 0.76-3.37). The rate of biochemical and hypertension cure was similar in both groups; however, hypertension cure tended to be more frequent in the non-smoker group (41.2% vs 29.9%, P = .076).Conclusions Patients with PA who smoke have a higher prevalence of LVH and MACS and larger adrenal nodule/s than non-smokers. Smoking has no significant effect on the probability of hypertension response after adrenalectomy in patients with PA; however, a tendency to a lower probability of hypertension cure is observed in smokers compared to non-smokers.

引用

页码：579 / 587

页数：9

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