Specialized pro-resolving mediator 7S MaR1 inhibits IL-6 expression via modulating ROS/p38/ERK/NF-κB pathways in PM10-exposed keratinocytes

被引：2

作者：

Kim, Jinju ^{[1
]}

Park, Hyo-Min ^{[1
]}

Lim, Chae-Min ^{[1
]}

Jeon, Kyeong-Bae ^{[1
]}

Kim, Seonhwa ^{[1
]}

Lee, Jin ^{[1
]}

Hong, Jin-Tae ^{[2
,3
]}

Oh, Deok-Kun ^{[1
]}

Yang, Young ^{[4
]}

Yoon, Do-Young ^{[1
]}

机构：

[1] Konkuk Univ, Dept Biosci & Biotechnol, Seoul 05029, South Korea

[2] Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, South Korea

[3] Chungbuk Natl Univ, Med Res Ctr, Cheongju 28160, South Korea

[4] Sookmyung Womens Univ, Dept Biol Sci, Seoul 04310, South Korea

来源：

BMB REPORTS | 2024年 / 57卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

7S epimer of maresin 1; HaCaT cells; MAPK; Nuclear factor-kappa B; Skin inflammation; AIRBORNE PARTICULATE MATTER; SKIN; INFLAMMATION; POLLUTION; DISEASES;

D O I：

10.5483/BMBRep.2024-0124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Keratinocytes are susceptible to airborne particulate matter (PM) exposure, resulting in human skin barrier dysfunction. Therefore, it is important to find useful reagents to resolve skin damages caused by PM. Here, we explored the protective effect of 7S MaR1, a specialized pro-resolving mediator derived from docosahexaenoic acid, on skin inflammation and the oxidative stress induced by PM with a diameter 10 mu m or less (PM10) in human keratinocyte HaCaT cells. Interestingly, PM10-induced ROS generation was modulated by 7S MaR1 via the recovery of ROS scavenger genes. 7S MaR1 reduced PM10-induced IL-6 expression via modulating the p38/ERK/NF-kappa B signaling pathways. These results demonstrate that PM10 induces inflammatory cytokines, which can lead to skin diseases. In addition, 7S MaR1 can resolve inflammation caused by PM10-induced oxidative stress and inflammatory cytokines.

引用

页码：490 / 496

页数：7

共 28 条

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