Hyperthermic response optimization for Mn0.5Zn0.5Fe2O4 magnetic fluid for its application in magnetic fluid hyperthermia

The present work reports the synthesis and characterization of Mn 0.5 Zn 0.5 Fe 2 O 4 ferrite nanoparticles-based magnetic fluid for magnetic fluid hyperthermia. The synthesis of Mn 0.5 Zn 0.5 Fe 2 O 4 is done using well-known co-precipitation, microwave, autoclave, and hydrothermal techniques. The XRD results confirm the pure and single-phase spinel structure for the samples synthesized using all the techniques. TEM images show the spherical shape of the particles in all four samples. All the samples are coated with polyethylene glycol as a surfactant to make the fluid biocompatible. The coating is confirmed by FTIR and TGA, whereas the stability of the magnetic fluids is measured by the zeta potential analyzer. The magnetic properties measured by VSM show that with the increase in the crystallinity and size of the samples, the domain magnetization of the particles increases. In the MFH, it is seen that the hyperthermia temperature window is successfully achieved when synthesized using a hydrothermal method. The results are discuss considering the improved crystallinity, size, saturation magnetization, and reduced polydispersity of the sample.