Reorganization of pragmatic language networks in patients with temporal lobe epilepsy

被引：0
作者：
Acevedo, Bautista Elizalde [1 ,2 ,3 ]
Kochen, Silvia [3 ]
Alba-Ferrara, Lucy [2 ,3 ]
Bendersky, Mariana [3 ,4 ]
机构：
[1] Univ Austral, CONICET, Inst Invest Med Traslac IIMT, Ave Peron 1500 B1629AHJ, Derqui-Pilar, Buenos Aires, Argentina
[2] Univ Austral, Fac Ciencias Biomed, Pilar, Buenos Aires, Argentina
[3] Consejo Nacl Invest Cient & Tecn CONICET, Unidad Ejecutora Estudio Neurociencias & Sistemas, Buenos Aires, Argentina
[4] Univ Buenos Aires, Fac Med, Catedra Anat Normal 3ra, Lab Anat Viviente, Buenos Aires, Argentina
来源：
CLINICAL NEUROPHYSIOLOGY | 2025年 / 170卷
关键词：
Metaphor; Connectivity; Network; Plasticity; Refractory; Temporal lobe epilepsy; RIGHT-HEMISPHERE; ATYPICAL LANGUAGE; STRUCTURAL CONNECTIVITY; SPOKEN LANGUAGE; TELL US; BRAIN; FMRI; LATERALIZATION; COMPREHENSION; COMMUNICATION;
D O I：
10.1016/j.clinph.2024.12.012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To investigate the neural networks involved in idiomatic expressions (IE) comprehension in healthy controls and patients with drug-resistant temporal lobe epilepsy (TLE), with a functional magnetic resonance imaging (fMRI) task. Methods: Thirty-two patients with TLE (left or right) and seventeen healthy controls were evaluated. Activated nodes in the fMRI task were defined as Regions of Interest (ROIs) for a posterior functional connectivity analysis. Results: All participants completed the task successfully. We found a bilateral fronto-temporal network, lateralized to the right, during IE processing in the overall sample. Compared to controls, patients additionally activated frontal, temporal, and insular areas in both hemispheres. Controls exhibited fewer connections but greater inhibitory connectivity, while the opposite (more connections and increased excitatory connectivity) occurred in patients. Compared to controls, TLE patients recruited additional brain areas on top of the expected bilateral frontotemporal network. The connectivity analysis revealed that controls exhibited more effective inhibitory connectivity, with more modular ROIs. In contrast, patients demonstrated greater excitatory connectivity. Conclusion: The results suggest compensatory neural recruitment in additional areas in TLE during IE comprehension. Significance: Exacerbated connections in TLE may reflect the need to recruit alternative regions, resulting in higher costs and lower efficiency of the neural network.
引用
收藏
页码：194 / 205
页数：12
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