Depressive disorder among gynecologic cancer survivors in the US: Evidence from the 2020 Behavioral Risk Factor Surveillance Survey

Objective: Patients with gynecologic cancers demonstrate different psychosocial outcomes based on their cancer site, which may affect treatment effectiveness and survivorship. Demographic differences and the relation with depression (DP) among women who have a gynecologic cancer diagnosis are not well understood. Methods: To assess whether survivors of gynecologic cancer had a greater risk of DP compared with women with and without a history of cancer, 2020 BRFSS data was utilized. Pearson chi-square and multivariable logistic regression were conducted to obtain adjusted odds ratios. Results: Prevalence of DP was 20 % higher among survivors of gynecologic cancer; this was consistent across race/ethnic and urban/rural categories. Odds of DP among gynecologic cancer survivors were 2.5xs those without any history of cancer. Among Black and Hispanic gynecologic cancer survivors, the adjusted odds of DP were 4.5 and 3.2 times those with no cancer or a history of any cancer. Conclusions: The odds of having DP were significantly higher among gynecologic cancer survivors compared to women without any history of cancer, breast cancer survivors, or survivors of other cancers.