A Causal Relationship between Type 2 Diabetes and Candidiasis through Two-Sample Mendelian Randomization Analysis

被引：0

作者：

Xiong, Juan ^{[1
]}

Lu, Hui ^{[1
]}

Jiang, Yuanying ^{[1
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Pharm, Shanghai 200092, Peoples R China

来源：

MICROORGANISMS | 2024年 / 12卷 / 10期

基金：

中国国家自然科学基金;

关键词：

type; 2; diabetes; candidiasis; genetic causal relationship; Mendelian randomization; VULVO-VAGINAL CANDIDIASIS; EPIDEMIOLOGY; INSTRUMENTS;

D O I：

10.3390/microorganisms12101984

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The potential relationship between type 2 diabetes (T2D) and candidiasis is of concern due to the respective characteristics of these conditions, yet the exact causal link between the two remains uncertain and requires further investigation. In this study, the inverse-variance-weighted (IVW) analysis indicated a significant genetic causal relationship between T2D and candidiasis (p = 0.0264, Odds Ratio [OR], 95% confidence interval [CI] = 1.1046 [0.9096-1.2996]), T2D (wide definition) and candidiasis (p = 0.0031, OR 95% [CI] = 1.1562 [0.8718-1.4406]), and severe autoimmune T2D and candidiasis (p = 0.0041, OR 95% [CI] = 1.0559 [0.9493-1.1625]). Additionally, the MR-Egger analyses showed a significant genetic causal relationship between T2D (wide definition) and candidiasis (p = 0.0154, OR 95% [CI] = 1.3197 [0.7760-1.8634]). The weighted median analyses showed a significant genetic causal relationship between severe autoimmune T2D and candidiasis (p = 0.0285, OR 95% [CI] = 1.0554 [0.9498-1.1610]). This Mendelian randomization (MR) study provides evidence for a genetic correlation between T2D and candidiasis.

引用

页数：17

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